MTHFR-Genetics, Autism, and Disease
MTHFR stands for MethylTetraHydroFolate Reductase Deficiency. MTHFR is a genetic disorder that inhibits some people from being able to convert folic acid from food to the active form of folic acid, L-methylfolate, that is used by the body. MTHFR was identified in the Human Genome Project, a study designed to identify treatable genetic disorders.
Methylenetetrahydrofolate reductase
Methylenetetrahydrofolate reductase (MTHFR) is the rate-limiting enzyme in the methyl cycle, and it is encoded by the MTHFR gene.[2] Methylenetetrahydrofolate reductase catalyzes the conversion of 5,10-methylenetetrahydrofolate to 5-methyltetrahydrofolate, a cosubstrate for homocysteine remethylation to methionine. Genetic variation in this gene may influence susceptibility to occlusive vascular disease, neural tube defects, dementia, colon cancer, and acute leukemia, because mutations in this gene are associated with methylenetetrahydrofolate reductase deficiency.[3][4]
This appears that is has been very possibly a highly overlooked issue in regard to triggering and causation of ASD. Quite obviously there would be in having this MTHFR/ as a remethylation defect condition, and in as well combined with situations of known less than adequate levels of glutathione, also known often present in those with existing diagnosis of autism, (ASD). When such a condition is present, quite obviously all vaccines would be contraindicated, and this condition appears to be much more prevalent than a person would think.
http://en.wikipedia.org/wiki/Methylenetetrahydrofolate_reductase
It’s NO Vaccident! Posted on October 23, 2013
Excerpts:
5. Individuals who have bio markers showing inefficient folate metabolism, impaired methylation, low glutathione levels, and vitamin deficiencies (including but not limited to B12, vitamin D, and carnitine deficiency), are also at high risk for adverse reactions to vaccines because their ability to rid some of the additives and preservatives is impaired, and because their methylation cycle and mitochondria may be impaired.
So my question to you is…. Is it a Vaccident?
Is it as random as a car crash,
Who is injured and who is not?
Or are there family histories, bio-markers, genetic testing, and nutritional screening that all need to be taken into account, prior to giving a vaccination (or medication, anesthesia, or supplement)? Is it a safe assumption that every child can tolerate the recommended vaccine schedule as recommended, regardless of their nutritional, immune, or genetic status, just as safe as it is to assume that every person riding in a car will tolerate an accident the same way, regardless of their seat-belt or car-seat status?
In order to uphold the Hippocratic oath for all children (and adults)-
“First, Do No Harm”
…we ALL must advocate to FIRST. DO. NO. HARM. to all people, but especially to those who are susceptible to succumbing to a VACCIDENT BEFORE that VACCINE INDUCED INJURY occurs.
http://babyfoodsteps.wordpress.com/2013/10/23/its-no-vaccident/
M is for Mitochondrial Disease
http://babyfoodsteps.wordpress.com/2011/01/31/m-is-for-mitochondrial-disease/
MTHFR, Folic Acid, and Mitochondrial Disease… is there a link?
Excerpts:
ONE BIG CLARIFICATION
FOLIC ACID is not the same thing as FOLATE!! Folic Acid (also called pteroylmonoglutamic acid) is SYNTHETIC and not found in nature… if you have the MTHFR mutation you cannot efficiently process and “methylate” folic acid to a useable form that your body can use (5MTHF)…. therefore you could take all the pre-natal (folic acid fortified) vitamins or multivitamins in the world…. but if your body cannot process/convert them correctly then your HEALTH is gaining LITTLE to NO benefit from them! So just adding more FOLIC acid (from fortified processed enriched foods) to your diet is NOT the cure… getting FOLATE in its natural form from foods(dark leafy greens, citrus, legumes, etc.) and supplementing the rest with a BIO ACTIVE form of FOLATE is HELPFUL.
If you would like an amazing over view of ALL the things that a defective MTHFR gene can cause, listen here to Dr. Ben Lynch of www.mthfr.net and see for yourself the implications:
http://babyfoodsteps.wordpress.com/2012/05/14/mthfr-mito-link/
Mito Action-April 2012 Topic
Excerpts:
What do we know about folate polymorphisms and autism?
Many doctors in the autism/biomed community use folinic acid supplements as a treatment for autism. Dr. Jill James et. al stated in 2004 that "Based on the observed MTHFR-related genetic variations in children with ASD, it is reasonable to evaluate dietary supplementation with folinic acid and its cofactors in the methylation cycle, e.g. B vitamins and trimethylglycine (Betaine), for these children. This would be particularly important in the subgroup shown to carry MTHFR polymorphisms."
Many children with autism have MTHFR-related genetic variations and it has been hypothesized that this may play a potential role in ASD symptomology. In an article published in 2004, Dr. Jill James et al. found that children with diagnosed ASD and MTHFR variants have approximately a 30-50% decrease in enzyme activity. To read this full article, please visit this link. http://www.jpands.org/vol9no4/boris.pdf
(There arel ots of related scientific studies on this Mito Action source page).
Article source page link. Read more.
http://www.mitoaction.org/autism/february-2012-teleconference
Folic Acid Fortification, Increase in MTHFR and Rise in Autism?
http://mthfr.net/folic-acid-fortification-increase-in-mthfr-and-rise-in-autism/2012/05/11/
More articles.
http://mthfr.net/blog/
MTHFR Research
http://mthfr.net/mthfr-research/2012/01/27/
MTHFR.net is the leading resource for unbiased, researched information strictly about the MTHFR mutation.
I believe the MTHFR gene mutation is a highly significant public health problem that is completely ignored. Yet, millions are suffering from pulmonary embolisms, addictions, fibromyalgia, miscarriages, schizophrenia, severe depression, cancer and autism to name a few.
What do these conditions have in common?
They all may be linked to a MTHFR gene mutation in the individual expressing these symptoms and health conditions.
If we can get MTHFR mutations on the map and get standardized medicine to begin screening for it, we can truly make a difference. The lab test to determine which MTHFR mutations are present is only about $150.00. That is nothing.
With all that said, you can see why I have created. http://mthfr.net/
Methylation and MTHFR Defects presented by Benjamin Lynch, ND
http://www.youtube.com/watch?v=QRHif2aVPvw&feature=player_embedded
What is Methylation and MTHFR
http://www.youtube.com/watch?v=ah2oHgQvj3A
Part 1 of 4 - Dr. Neil Rawlins gives an insightful 51-minute lecture on MTHFR (Methyltetrahydrofolate Reductase) in September of 2011. In it he covers what MTHFR is, what the symptoms of MTHFR are, as well as how to treat it and some of the products available to do so. He also covers some clinical trial information as well. He is incredibly informative on the topic as he has been studying it in earnest for over 5 years now. The near death of his son propelled him to embark on a personal journey to learn all about MTHFR and treat it in his family. Dr. Rawlins has treated hundreds of patients with great success.
http://www.youtube.com/watch?v=ZA8GUIRqIkE
http://www.youtube.com/watch?v=BM3RXJ28I2Q
http://www.youtube.com/watch?v=nYoGrqdMCaU
http://www.youtube.com/watch?v=JEeedfavEeE
MTHFR, Autism, and Homocysteine Symptoms Need a Methylfolate Solution
Check out www.methyl-life.com for more MTHFR information.
MTHFR Information
http://www.rawlins.org/mthfr/mthfr.html
Dr Neil Rawlins, MTHFER
http://vimeo.com/33039195
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MOVE OVER, MTHFR: TIME TO LOOK AT COMT
Jared M. Skowron, ND
After giving methylfolate to hundreds of patients, I noticed some of them responded with aggression, anxiety, anger, and irritability. When they stopped their supplementation, the side effects resolved. While many practitioners adjust dose, add methylcobalamin, or various amino acids, I wanted to go deeper into the genetic pathology. Treat the cause, right?
WHAT ARE MTHFR AND COMT?
MTHFR activates 5,10-methylenetetrahydrofolate to 5-methyltetrahydrofolate (5-MTHF). While m
is a key enzyme involved in serotonin, dopamine, and catecholamine production, catechol-O-methyltransferase (COMT) is the enzyme responsible for degradation of catecholamines. Focusing primarily on epinephrine as our major example, if COMT is not metabolizing effectively (the result of carrying a polymorphism in the gene), epinephrine will build up, potentially leading to aggression, anxiety, anger, etc. The metaphor always comes down to plumbing: if we open the flood gates of neurotransmitter production with methylfolate supplementation, but the exit pipe is small, it’s like putting a thumb over a rushing garden hose…. Explosion!
SORTING IT OUT IN YOUR PATIENTS
Read more:
http://ndnr.com/pediatrics/move-over-mthfr/
What are single nucleotide polymorphisms (SNPs)?
http://unesdoc.unesco.org/images/0014/001461/146180E.pdf
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G is for Glutathione, (and is necessary to make Methyl folate)
Article excerpts:
I have blogged about Glutathione a few times, here (acetaminophen/Tylenol LOWERS glutathione) and here (and so does aspartame). I am revisiting it today, in light of some recent blood work that we got back for Lady A and some new research I have done, that I feel VERY compelled to share, because I think this Mighty Chemical Glutathione {G} has implications in ALL OF OUR HEALTH!
(The article contains many related informational videos).
http://babyfoodsteps.wordpress.com/2012/11/12/g-is-for-glutathione/
Glutathione, Tylenol, Vaccine Adverse Reactions, and ASD
http://www.vacfacts.info/glutathione-tylenol-vaccine-adverse-reactions-and-asd.html
Why is Glutathione critical to health and even life?
http://www.youtube.com/watch?v=-Ln6WCLCw2k
Glutathione Increased By 300% In 24 Hours! hope for autism
http://www.youtube.com/watch?v=ARqxtIyCdDs&feature=share&list=PL66ySoeczkU8l5MdCZBvvTldM18hbwD7q
Suzanne Somers discusses Glutathione Patches
http://www.youtube.com/watch?v=gBFTre-Y1eo
Glutathione: A Key Anti-Inflammatory
http://www.youtube.com/watch?v=JI2Oo_MZjYY
Glutathione: The Master Antioxidant
http://www.youtube.com/watch?v=2VRzcOBJs0s&list=PL66ySoeczkU8l5MdCZBvvTldM18hbwD7q
Why is Glutathione critical to health and even life?
http://www.youtube.com/watch?v=-Ln6WCLCw2k
What is Glutathione and How Do I Get More of It? - Dr. Mark Hyman
http://drhyman.com/blog/2010/05/12/what-is-glutathione-and-how-do-i-get-more-of-it/#close
Essential Glutathione: The Mother of All Antioxidants - Dr. Mark Hyman
9 Tips to Optimize your Glutathione Levels
These 9 tips will help you improve your glutathione levels, improve your health, optimize your performance and live a long, healthy life.
Eat Foods that Support Glutathione Production
Besides taking a multivitamin and fish oil, supporting my glutathione levels with these supplements is the most important thing I do every day for my personal health
http://drhyman.com/blog/2010/05/19/glutathione-the-mother-of-all-antioxidants/
Is Inflammation: The Root Cause of All Disease? Dr Mayer Eisenstein
http://www.youtube.com/watch?v=j0oUuyBd-Gc
What are vaccines? Inflammatory. Aluminum vaccine adjuvants main effect at least one of them, is the production of inflammation insofar as as well being causation increasing and heightened immune system hyper-reativity to such as so called killed attenuated vaccines. Vaccines that otherwise could not produce enough immune system reactivity to even develop any form of recognized as sufficient number increased antibodies to in effect be equivalent to what they believe standardly results in immunity, and in turn hopefully real life efficacy against the targeted illness.
When you additionally have vaccines causing as well over-activation of the brains microglia cells, and in turn extended time periods of low level chronic brain inflammation, thus we additional have this causation and result in regard to the harm vaccines and multiple vaccines are doing. Also in the connection to ASD. More and more studies have made that finding of chronic levels of brain inflammation in those with ASD, and as well ADHD. But this is a part of the tip of the vaccine harm iceberg; as other factors are as well in play. Information source, Dr Russell Blaylock and many independent scientific studies.
In many disease processes and as well that regarding autism, Parkinsons, heart disease, and much more we can see the same mechanism of causation, and also involving so called oxidative stress. As to this MTHFR-Genetics, Autism, information and Disease, again oxidative stress is again a factor. So, what is the complete definition of oxidative stress and in its physiological applications regarding harm and resulting adverse health effects. By some or many sources it does seem to a concept that is somewhat well understood, but yet it clearly seems to NOT be fully understood, as it would and should need to be.
Oxidative stress
http://en.wikipedia.org/wiki/Oxidative_stress
What is Oxidative Stress?
http://www.news-medical.net/health/What-is-Oxidative-Stress.aspx
This one product Protandim just may go a long way in treating MTHFR disorder. In fact it is known as one of the best supplement products in maintaining over-all general health, that exist.
Protandim is a daily dietary supplement that combats oxidative stress through Nrf2 activation.
http://www.lifevantage.com/products/protandim/
What is Nrf2
Nrf2 is a protein that binds itself to a DNA sequence. Nrf2 enters cells to stimulate protective genes and enzymes to neutralize the effects of free radicals.
http://www.protandim.com/nrf2/
MTHFR genetic defect – what it is and how it can affect you
http://www.stopthethyroidmadness.com/mthfr/
Related to the directly above article, these subject matter statements were in reply to it made by Pat Hatwan, who I consider a very knowledgeable person in the field.
Bernie Rimmland had the best ...universal understanding of any of them...THEN?...Moulden tied it up...nicely. He and I discussed----GENE SHUNTS and ENZYME DERAILMENTS.....and we were UNAWARE that Protandim was already on the market....we simply did not know.
Here is an issue UNTOUCHED in this article...MAGNESIUM
a few years ago?...the HYPERSTERS tried to get everyone CONVINCED they could supplement with SAM-e.
IT DIDN'T work
IF the liver does not go through Methylation, Hydroxylation and glucaronidation?.....detoxification processes are NOT carried out
so...again....yes..I look STRONGLY at how to "modulate" the genome...into correct expression. OF about 400 "survivor gene expressions"...that get properly modulated?....they speak to roughly 8000 to 12,000 genes...all appropriately modulated then
it is NOT a stand alone....I also believe STRONGLY in monosacharide supplementation...
and ?...magnesium chloride, idoine, selenomethionine...baking soda....etc...
The MTHER gene MUST be associating with thousands of other gene expressions...and IF a series of or a significant number of genes are SHUNTED?....we have a failure to communicate Houston..
So...attempting to supplement with B3?....not fully effective...or B6 or B12..etc?..for mental function/cognition approaches.
and IF we're deficient proper nurition?.....say we're Eskimo....and we're being fed plant based foods?...we're going to MAGNIFY and COMPOUND the problems.
and?....age related gene expression must be addressed.
Some genes express in youth and infancy that DO NOT express in adolescence or adulthood...so that must be addressed.
We're being SHIFTED UNMERCIFULLY by hucksters...or?...by limited information from inside a community that is MISINFORMED.....which ALL of modern medicine qualifies for....as does ACADEMIA.
one thing that has been OMITTED?....over the last 40 years?...is glyphosate. From the beginning of the Viet Nam war?...until today?....we see the relationship of glyphosate contamination equal with the INCREASE of all autoimmune diseases..to include autism....
1st----the younger the easier and better and quicker.....PROTANDIM for every living soul on earth.
EVERYONE is deficient magnesium ...in chloride form
Detoxified iodine MUST be used....we're overloaded with fluoride, bromide, and chloride
selenomethionine supplemented with detoxified iodine?...A MERCURY MAGNET....but setting proper gene expression...so chelation and excretion processes are in place?...A MUST
and?....endogenous production of gluthione enzymes, catalase and SOD MUST be established.
otherwise?.....we'll be walking the dog
appropriate foods for our genetic makeup is a MUST also
we MUST NOT get caught up in this NOTION of genes are our future....and BAD GENES exist...(THAT IS WRONG)....genes express ..either appropriately or not
THIS Is why....this what glut does...
BUT NOT SUPPLEMENTED glut
BUT NOT SUPPLEMENTED glut..or IV
endogenously produced...but upregulation of the genes required for production
These are the 1st noticable responses by glut produced by our bodies...and autistic kids are deficient glut...because of GENE SHUNTS..
This one is NOT a protandim study...but looks at other MINOR "upregulator" process supplements:
http://www.sciencedirect.com/science/article/pii/S2213231713000645
Here is another one I like....but STILL not Protandim related....
http://www.hindawi.com/journals/omcl/2011/689524/
Here are 3 PubMed articles on the upregulation of Glut via Protandim:
http://www.ncbi.nlm.nih.gov/pubmed/?term=Protandim+and+glutathione
but do remember----it is NOT just glut that is crucial....ALL disease is rooted in free radical assault...resulting in oxidative stress....SO?....there must be a scavenger to reduce these assaults.....and that is where SOD comes into play
BUT?...the binding process is related to KEAP1...which is crucial in the Nrf2 protein that MUST enter the nucleus of every cell...to CLEAN THEM UP
this...the nucleus of every cell....?...is where the REAL WORK is performed
You can go to any health food store...purchase Atomidine and Selenomethionine
they are both available.....and will cost about $40.00 your first purchaasse...then.use bapproximatelly 300 mcg of the selenomethionine and 4 to 6 drops of the Atomidine
...daily
do the Atomindine FIRST thing in the morning...30 minutes away from any food....in CLEAN WATER ....about 4 to 6 oz water
NOW?...we need to pay EXTRA SPECIAL ATTENTION to how they...THEY are blocking the sun's frequencies...how they are damaging the water and the food and the soil...with ROUNDUP
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Here we have the FDA sticking their nose in everything again, and preventing people from really knowing what goes on with their health. Thus it is stated that you will need to get the test result interpreted by one of the sources that can interpret these tests. Oh yes and it states as well that the test requires first a doctors prescription, and while of course most pharma trained doctors are clueless about the MTHR defect. You know to actually figure out causation of any health situation, that does not fall under their parameters and of the scope of their practice. Prescribing drugs that fit a diagnosis that will pay under the insurance codes, oh that they can do, however. A profit sick system it is, in deed.
Status of our health-related genetic reports.
We no longer offer our health-related genetic reports to new customers to comply with the U.S. Food and Drug Administration’s directive to discontinue new consumer access during our regulatory review process.
At this time, we do not know the timeline as to which health reports might be available in the future or when they might be available.
https://www.23andme.com/health/
https://www.23andme.com/howitworks/
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And how soon do you think Offit and the CDC will be onto addressing this information? They never will be because it still directly or at the least indirectly implicates as well, vaccines. This is actually the state of science that should exist, instead of the refusing to look outside the box that does exist.
The MTHFR Connection
http://mthfrliving.com/andreas-diary/mthfr-gene-mutation/
Autism, imprinting and epigenetic disorders: a metabolic syndrome linked to anomalies in homocysteine recycling starting in early life??
http://link.springer.com/article/10.1007%2Fs10815-011-9645-2
MTHFR-Genetics, Autism, and Disease
Aberrations in folate metabolic pathway and altered susceptibility to autism.
http://www.ncbi.nlm.nih.gov/pubmed/19440165
MTHFR gene mutation… What’s the big deal about Methylation?
http://doccarnahan.blogspot.com/2013/05/mthfr-gene-mutation-whats-big-deal.html
Autism Spectrum Disorder-associated Biomarkers for Case Evaluation and Management by Clinical Geneticists
Genetic abnormalities are common among ASDs. Therefore, it is important that affected families seek genetic counseling to determine the family risk of transmission of ASD-associated genes, as well as to provide insights into behavior modification in order to help reduce the impact of genetic polymorphisms.
http://www.medscape.com/viewarticle/584398_7
Common genetic polymorphisms can increase risk of autism spectrum disorders
The contribution of inheritance and genetic mutation versus environmental factors to the risk of ASD is hotly debated. Most twin studies show the contribution heavily tilted toward inheritance, but the exact amount of involvement of genes in ASD risk is less apparent. This is because, while the impact of rare genetic variations on ASD risk is becoming clear, the role of more common variations, so called single nucleotide polymorphisms (SNP), remains unresolved.
By analyzing one million of the common variations in each participant’s genome, it became clear that, in families where only one child is affected, 40% of the risk of ASD is inherited. In families where more than one child is affected this increased to over 60%. By looking in more detail at the unaffected parents and siblings of children with ASD it appeared that the inherited risk was additive.
http://www.news-medical.net/news/20121015/Common-genetic-polymorphisms-can-increase-risk-of-autism-spectrum-disorders.aspx
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How Vaccines Dysregulate The Immune System
http://gdsajj.wordpress.com/2011/08/05/how-vaccines-dysregulate-the-immune-system/
Vaccinations Cause Chronic Immune System Dysregulation
http://www.liveto110.com/vaccinations-cause-chronic-immune-system-dysregulation/
An Immune Disorder at the Root of Autism
So here’s the short of it: At least a subset of autism — perhaps one-third, and very likely more — looks like a type of inflammatory disease. And it begins in the womb. [No it does NOT, and that is not necessarily true, unless the mother has taken a Thimerosal containing flu vaccine, or such as an aluminum adjuvant containing DTaP vaccine. Much of this dysregulation can clearly happen after birth, and of course infants are vaccinated, from birth.]
It starts with what scientists call immune dysregulation. Ideally, your immune system should operate like an enlightened action hero, meting out inflammation precisely, accurately and with deadly force when necessary, but then quickly returning to a Zen-like calm. Doing so requires an optimal balance of pro- and anti-inflammatory muscle.
In autistic individuals, the immune system fails at this balancing act. Inflammatory signals dominate. Anti-inflammatory ones are inadequate. A state of chronic activation prevails. And the more skewed toward inflammation, the more acute the autistic symptoms.
Nowhere are the consequences of this dysregulation more evident than in the autistic brain. Spidery cells that help maintain neurons — called astroglia and microglia — are enlarged from chronic activation. Pro-inflammatory signaling molecules abound. Genes involved in inflammation are switched on.
These findings are important for many reasons, but perhaps the most noteworthy is that they provide evidence of an abnormal, continuing biological process. That means that there is finally a therapeutic target for a disorder defined by behavioral criteria like social impairments, difficulty communicating and repetitive behaviors.
http://www.nytimes.com/2012/08/26/opinion/sunday/immune-disorders-and-autism.html/?pagewanted=all&_r=0
A Mouse Model for the Immune Dysregulation Subtype of Autism, (And they would still claim to that there is no way vaccines have and can cause autism? That conclusion is of course clearly preposterous.)
http://tacanowblog.com/2012/07/23/a-mouse-model-for-the-immune-dysregulation-subtype-of-autism/
Vaccines and Autism, ADHD and Asthma
Immunizations and the Immunocompromised
"Yet, no doctor is trained to look for this type of immunodeficiency and/or the kind of immune dysregulation that multiple vaccine can cause; which lead to so called inflammatory syndromes and resulting overactivation of the brains microglia cells and resulting chronic levels of brain inflammation now ever more increasingly found in studies of those with autism. Vaccine aluminum adjuvants in several studies have been fund as well to in itself cause this stated inflammation.
http://www.epidemicanswers.org/vaccines-and-autism-adhd-and-asthma/
Immune Deficiencies
Antibodies (or Immunoglobins)
Concentrations of IL-12 and interferon gamma are much higher in the blood of children with autism than in normal children, indicating an immune activation, possibly due to adverse vaccine reactions. An optimal immune response to Candida infections necessitates a finely tuned balance of interferon gamma production; the dysregulation of the immune system, caused by IL-12-induced increases in gamma interferon, leads to increased Candida susceptibility in animals.
Read more:
http://www.greatplainslaboratory.com/home/eng/immunedeficiencies.asp
The immune response in autism: a new frontier for autism research
Immune aberrations consistent with a dysregulated immune response, which so far, have been reported in autistic children, include abnormal or skewed T helper cell type 1 (TH1)/TH2 cytokine profiles, decreased lymphocyte numbers, decreased T cell mitogen response, and the imbalance of serum immunoglobulin levels. In addition, autism has been linked with autoimmunity and an association with immune-based genes including human leukocyte antigen (HLA)-DRB1 and complement C4 alleles described.
Read more:
http://www.jleukbio.org/content/80/1/1.long
Study links vaccine induced immune overload to autism, diabetes, obesity
A new vaccine study published in Molecular and Genetic Medicine is bringing to the forefront the disturbing connection between the dramatic expansion in the quantity of routine childhood vaccines administered and a corresponding increase in inflammation-associated disorders.
Titled, "Review of Vaccine Induced Immune Overload and the Resulting Epidemics of Type 1 Diabetes and Metabolic Syndrome, Emphasis on Explaining the Recent Accelerations in the Risk of Prediabetes and other Immune Mediated Diseases," the study argues that vaccine-induced immune overload is a driving factor in a number of rapidly accelerating childhood epidemics including:
Autism
Type 1 diabetes
Asthma
Food allergies
Many autoimmune diseases
Obesity
Type 2 diabetes
Non-alcoholic fatty liver disease (NAFL)
Metabolic disease.
http://www.sott.net/article/279911-Study-links-vaccine-induced-immune-overload-to-autism-diabetes-obesity
http://www.organicconsumers.org/articles/article_30175.cfm
Review of Vaccine Induced Immune Overload and the Resulting Epidemics of Type 1 Diabetes and Metabolic Syndrome, Emphasis on Explaining the Recent Accelerations in the Risk of Prediabetes and other Immune Mediated Diseases
Abstract Background: Epidemics of type 1 diabetes had been linked to inflammation. Previous reports have suggested the prevalence of autism is increased in patients with type 1diabetes.
Methods: Medline and Google searches were performed in late 2010 to find a country where there was simulta-neous data on the incidence or prevalence of type 1 diabetes, type 2 diabetes and autism in multiple different races. The association between prevalence of autism in children and the incidence of type 1 diabetes or type 2 diabetes in children, when stratified by race, was studied.
Results: The prevalence of autism has a statistically significant positive association with the incidence of type 1 diabetes but has a statistically significant inverse association with type 2 diabetes.
Conclusion: This suggests that patients with autoimmune autism likely represent a large subset of patients with autism and that the etiology of the epidemic of autoimmune/inflammation mediated autism in children is likely to be related to the etiology of the simultaneous epidemic of type 1 diabetes in children.
http://www.omicsonline.com/open-access/vaccine-induced-immune-overload-and-the-resulting-epidemics-of-type-diabetes-and-metabolic-syndrome-1747-0862.S1-025.php?aid=24058
Autoimmune Disorders Caused by Vaccines
http://healthimpactnews.com/2012/autoimmune-disorders-caused-by-vaccines/
Self-Organized Criticality Theory of Autoimmunity
Conclusions/Significance
Systemic autoimmunity appears to be the inevitable consequence of over-stimulating the host's immune ‘system’ by repeated immunization with antigen, to the levels that surpass system's self-organized criticality.
http://www.plosone.org/article/info:doi%2F10.1371%2Fjournal.pone.0008382
How Do Vaccines Work? Immune Mechanisms and Consequences
http://pathwaystofamilywellness.org/component/option,com_crossjoomlaarticlemanager/Itemid,375/aid,1369/view,crossjoomlaarticlemanager/#sthash.rkJSugBv.dpuf
Your Immune System, How It Works And How Vaccines Damage It
http://www.vaccineriskawareness.com/Your-Immune-System-How-It-Works-And-How-Vaccines-Damage-It
Anatomy and Physiology of the Immune System, Part 4
How pharmaceuticals destroy nature
http://jonbarron.org/article/anatomy-and-physiology-immune-system-part-4#.UwH0pvldXbY
Understanding immunity requires more than immunology
http://www.nature.com/ni/journal/v11/n7/full/ni0710-561.html
Warning to Pregnant Mothers - Toxic Dose of Aluminum in the Tdap
Paul Thomas, Pediatrician
http://www.youtube.com/watch?v=VoY6vXEMsU8
Aluminum in Vaccines | A Pediatricians Warning To All Parents
http://www.youtube.com/watch?v=ee70I5bm3-k
Antibodies (or Immunoglobins)
The B-lymphocyte cells of the immune system produce antibodies called immunoglobulins. These antibodies are designed to react against specific antigens (or foreign molecules) introduced into the system by various types of microorganisms. Antibodies react against microorganisms (viruses, yeast, parasites, and bacteria) and allow them to be killed by the white blood cells. Composed mostly of amino acids, antibodies are proteins that are divided into five major antibody classes (IgM, IgG, IgE, IgA, IgD). Each antibody class has a unique chemical structure and a specific function. IgG stands for immunoglobulin G or antibody G and so forth. Each class contains thousands of different antibodies to different microorganisms, foods, and chemicals.
http://www.greatplainslaboratory.com/home/eng/immunedeficiencies.asp
As you can see, and for reasons noted here and due to inadequate detoxification ability; for those
MethylTetraHydroFolate Reductase Deficiency/Disorder, (MTHFR); vaccines would be obviously and highly contraindicated for use.
MTHFR stands for MethylTetraHydroFolate Reductase Deficiency. MTHFR is a genetic disorder that inhibits some people from being able to convert folic acid from food to the active form of folic acid, L-methylfolate, that is used by the body. MTHFR was identified in the Human Genome Project, a study designed to identify treatable genetic disorders.
Methylenetetrahydrofolate reductase
Methylenetetrahydrofolate reductase (MTHFR) is the rate-limiting enzyme in the methyl cycle, and it is encoded by the MTHFR gene.[2] Methylenetetrahydrofolate reductase catalyzes the conversion of 5,10-methylenetetrahydrofolate to 5-methyltetrahydrofolate, a cosubstrate for homocysteine remethylation to methionine. Genetic variation in this gene may influence susceptibility to occlusive vascular disease, neural tube defects, dementia, colon cancer, and acute leukemia, because mutations in this gene are associated with methylenetetrahydrofolate reductase deficiency.[3][4]
This appears that is has been very possibly a highly overlooked issue in regard to triggering and causation of ASD. Quite obviously there would be in having this MTHFR/ as a remethylation defect condition, and in as well combined with situations of known less than adequate levels of glutathione, also known often present in those with existing diagnosis of autism, (ASD). When such a condition is present, quite obviously all vaccines would be contraindicated, and this condition appears to be much more prevalent than a person would think.
http://en.wikipedia.org/wiki/Methylenetetrahydrofolate_reductase
It’s NO Vaccident! Posted on October 23, 2013
Excerpts:
5. Individuals who have bio markers showing inefficient folate metabolism, impaired methylation, low glutathione levels, and vitamin deficiencies (including but not limited to B12, vitamin D, and carnitine deficiency), are also at high risk for adverse reactions to vaccines because their ability to rid some of the additives and preservatives is impaired, and because their methylation cycle and mitochondria may be impaired.
So my question to you is…. Is it a Vaccident?
Is it as random as a car crash,
Who is injured and who is not?
Or are there family histories, bio-markers, genetic testing, and nutritional screening that all need to be taken into account, prior to giving a vaccination (or medication, anesthesia, or supplement)? Is it a safe assumption that every child can tolerate the recommended vaccine schedule as recommended, regardless of their nutritional, immune, or genetic status, just as safe as it is to assume that every person riding in a car will tolerate an accident the same way, regardless of their seat-belt or car-seat status?
In order to uphold the Hippocratic oath for all children (and adults)-
“First, Do No Harm”
…we ALL must advocate to FIRST. DO. NO. HARM. to all people, but especially to those who are susceptible to succumbing to a VACCIDENT BEFORE that VACCINE INDUCED INJURY occurs.
http://babyfoodsteps.wordpress.com/2013/10/23/its-no-vaccident/
M is for Mitochondrial Disease
http://babyfoodsteps.wordpress.com/2011/01/31/m-is-for-mitochondrial-disease/
MTHFR, Folic Acid, and Mitochondrial Disease… is there a link?
Excerpts:
ONE BIG CLARIFICATION
FOLIC ACID is not the same thing as FOLATE!! Folic Acid (also called pteroylmonoglutamic acid) is SYNTHETIC and not found in nature… if you have the MTHFR mutation you cannot efficiently process and “methylate” folic acid to a useable form that your body can use (5MTHF)…. therefore you could take all the pre-natal (folic acid fortified) vitamins or multivitamins in the world…. but if your body cannot process/convert them correctly then your HEALTH is gaining LITTLE to NO benefit from them! So just adding more FOLIC acid (from fortified processed enriched foods) to your diet is NOT the cure… getting FOLATE in its natural form from foods(dark leafy greens, citrus, legumes, etc.) and supplementing the rest with a BIO ACTIVE form of FOLATE is HELPFUL.
If you would like an amazing over view of ALL the things that a defective MTHFR gene can cause, listen here to Dr. Ben Lynch of www.mthfr.net and see for yourself the implications:
http://babyfoodsteps.wordpress.com/2012/05/14/mthfr-mito-link/
Mito Action-April 2012 Topic
Excerpts:
What do we know about folate polymorphisms and autism?
Many doctors in the autism/biomed community use folinic acid supplements as a treatment for autism. Dr. Jill James et. al stated in 2004 that "Based on the observed MTHFR-related genetic variations in children with ASD, it is reasonable to evaluate dietary supplementation with folinic acid and its cofactors in the methylation cycle, e.g. B vitamins and trimethylglycine (Betaine), for these children. This would be particularly important in the subgroup shown to carry MTHFR polymorphisms."
Many children with autism have MTHFR-related genetic variations and it has been hypothesized that this may play a potential role in ASD symptomology. In an article published in 2004, Dr. Jill James et al. found that children with diagnosed ASD and MTHFR variants have approximately a 30-50% decrease in enzyme activity. To read this full article, please visit this link. http://www.jpands.org/vol9no4/boris.pdf
(There arel ots of related scientific studies on this Mito Action source page).
Article source page link. Read more.
http://www.mitoaction.org/autism/february-2012-teleconference
Folic Acid Fortification, Increase in MTHFR and Rise in Autism?
http://mthfr.net/folic-acid-fortification-increase-in-mthfr-and-rise-in-autism/2012/05/11/
More articles.
http://mthfr.net/blog/
MTHFR Research
http://mthfr.net/mthfr-research/2012/01/27/
MTHFR.net is the leading resource for unbiased, researched information strictly about the MTHFR mutation.
I believe the MTHFR gene mutation is a highly significant public health problem that is completely ignored. Yet, millions are suffering from pulmonary embolisms, addictions, fibromyalgia, miscarriages, schizophrenia, severe depression, cancer and autism to name a few.
What do these conditions have in common?
They all may be linked to a MTHFR gene mutation in the individual expressing these symptoms and health conditions.
If we can get MTHFR mutations on the map and get standardized medicine to begin screening for it, we can truly make a difference. The lab test to determine which MTHFR mutations are present is only about $150.00. That is nothing.
With all that said, you can see why I have created. http://mthfr.net/
Methylation and MTHFR Defects presented by Benjamin Lynch, ND
http://www.youtube.com/watch?v=QRHif2aVPvw&feature=player_embedded
What is Methylation and MTHFR
http://www.youtube.com/watch?v=ah2oHgQvj3A
Part 1 of 4 - Dr. Neil Rawlins gives an insightful 51-minute lecture on MTHFR (Methyltetrahydrofolate Reductase) in September of 2011. In it he covers what MTHFR is, what the symptoms of MTHFR are, as well as how to treat it and some of the products available to do so. He also covers some clinical trial information as well. He is incredibly informative on the topic as he has been studying it in earnest for over 5 years now. The near death of his son propelled him to embark on a personal journey to learn all about MTHFR and treat it in his family. Dr. Rawlins has treated hundreds of patients with great success.
http://www.youtube.com/watch?v=ZA8GUIRqIkE
http://www.youtube.com/watch?v=BM3RXJ28I2Q
http://www.youtube.com/watch?v=nYoGrqdMCaU
http://www.youtube.com/watch?v=JEeedfavEeE
MTHFR, Autism, and Homocysteine Symptoms Need a Methylfolate Solution
Check out www.methyl-life.com for more MTHFR information.
MTHFR Information
http://www.rawlins.org/mthfr/mthfr.html
Dr Neil Rawlins, MTHFER
http://vimeo.com/33039195
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MOVE OVER, MTHFR: TIME TO LOOK AT COMT
Jared M. Skowron, ND
After giving methylfolate to hundreds of patients, I noticed some of them responded with aggression, anxiety, anger, and irritability. When they stopped their supplementation, the side effects resolved. While many practitioners adjust dose, add methylcobalamin, or various amino acids, I wanted to go deeper into the genetic pathology. Treat the cause, right?
WHAT ARE MTHFR AND COMT?
MTHFR activates 5,10-methylenetetrahydrofolate to 5-methyltetrahydrofolate (5-MTHF). While m
is a key enzyme involved in serotonin, dopamine, and catecholamine production, catechol-O-methyltransferase (COMT) is the enzyme responsible for degradation of catecholamines. Focusing primarily on epinephrine as our major example, if COMT is not metabolizing effectively (the result of carrying a polymorphism in the gene), epinephrine will build up, potentially leading to aggression, anxiety, anger, etc. The metaphor always comes down to plumbing: if we open the flood gates of neurotransmitter production with methylfolate supplementation, but the exit pipe is small, it’s like putting a thumb over a rushing garden hose…. Explosion!
SORTING IT OUT IN YOUR PATIENTS
Read more:
http://ndnr.com/pediatrics/move-over-mthfr/
What are single nucleotide polymorphisms (SNPs)?
http://unesdoc.unesco.org/images/0014/001461/146180E.pdf
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G is for Glutathione, (and is necessary to make Methyl folate)
Article excerpts:
I have blogged about Glutathione a few times, here (acetaminophen/Tylenol LOWERS glutathione) and here (and so does aspartame). I am revisiting it today, in light of some recent blood work that we got back for Lady A and some new research I have done, that I feel VERY compelled to share, because I think this Mighty Chemical Glutathione {G} has implications in ALL OF OUR HEALTH!
(The article contains many related informational videos).
http://babyfoodsteps.wordpress.com/2012/11/12/g-is-for-glutathione/
Glutathione, Tylenol, Vaccine Adverse Reactions, and ASD
http://www.vacfacts.info/glutathione-tylenol-vaccine-adverse-reactions-and-asd.html
Why is Glutathione critical to health and even life?
http://www.youtube.com/watch?v=-Ln6WCLCw2k
Glutathione Increased By 300% In 24 Hours! hope for autism
http://www.youtube.com/watch?v=ARqxtIyCdDs&feature=share&list=PL66ySoeczkU8l5MdCZBvvTldM18hbwD7q
Suzanne Somers discusses Glutathione Patches
http://www.youtube.com/watch?v=gBFTre-Y1eo
Glutathione: A Key Anti-Inflammatory
http://www.youtube.com/watch?v=JI2Oo_MZjYY
Glutathione: The Master Antioxidant
http://www.youtube.com/watch?v=2VRzcOBJs0s&list=PL66ySoeczkU8l5MdCZBvvTldM18hbwD7q
Why is Glutathione critical to health and even life?
http://www.youtube.com/watch?v=-Ln6WCLCw2k
What is Glutathione and How Do I Get More of It? - Dr. Mark Hyman
http://drhyman.com/blog/2010/05/12/what-is-glutathione-and-how-do-i-get-more-of-it/#close
Essential Glutathione: The Mother of All Antioxidants - Dr. Mark Hyman
9 Tips to Optimize your Glutathione Levels
These 9 tips will help you improve your glutathione levels, improve your health, optimize your performance and live a long, healthy life.
Eat Foods that Support Glutathione Production
Besides taking a multivitamin and fish oil, supporting my glutathione levels with these supplements is the most important thing I do every day for my personal health
http://drhyman.com/blog/2010/05/19/glutathione-the-mother-of-all-antioxidants/
Is Inflammation: The Root Cause of All Disease? Dr Mayer Eisenstein
http://www.youtube.com/watch?v=j0oUuyBd-Gc
What are vaccines? Inflammatory. Aluminum vaccine adjuvants main effect at least one of them, is the production of inflammation insofar as as well being causation increasing and heightened immune system hyper-reativity to such as so called killed attenuated vaccines. Vaccines that otherwise could not produce enough immune system reactivity to even develop any form of recognized as sufficient number increased antibodies to in effect be equivalent to what they believe standardly results in immunity, and in turn hopefully real life efficacy against the targeted illness.
When you additionally have vaccines causing as well over-activation of the brains microglia cells, and in turn extended time periods of low level chronic brain inflammation, thus we additional have this causation and result in regard to the harm vaccines and multiple vaccines are doing. Also in the connection to ASD. More and more studies have made that finding of chronic levels of brain inflammation in those with ASD, and as well ADHD. But this is a part of the tip of the vaccine harm iceberg; as other factors are as well in play. Information source, Dr Russell Blaylock and many independent scientific studies.
In many disease processes and as well that regarding autism, Parkinsons, heart disease, and much more we can see the same mechanism of causation, and also involving so called oxidative stress. As to this MTHFR-Genetics, Autism, information and Disease, again oxidative stress is again a factor. So, what is the complete definition of oxidative stress and in its physiological applications regarding harm and resulting adverse health effects. By some or many sources it does seem to a concept that is somewhat well understood, but yet it clearly seems to NOT be fully understood, as it would and should need to be.
Oxidative stress
http://en.wikipedia.org/wiki/Oxidative_stress
What is Oxidative Stress?
http://www.news-medical.net/health/What-is-Oxidative-Stress.aspx
This one product Protandim just may go a long way in treating MTHFR disorder. In fact it is known as one of the best supplement products in maintaining over-all general health, that exist.
Protandim is a daily dietary supplement that combats oxidative stress through Nrf2 activation.
http://www.lifevantage.com/products/protandim/
What is Nrf2
Nrf2 is a protein that binds itself to a DNA sequence. Nrf2 enters cells to stimulate protective genes and enzymes to neutralize the effects of free radicals.
http://www.protandim.com/nrf2/
MTHFR genetic defect – what it is and how it can affect you
http://www.stopthethyroidmadness.com/mthfr/
Related to the directly above article, these subject matter statements were in reply to it made by Pat Hatwan, who I consider a very knowledgeable person in the field.
Bernie Rimmland had the best ...universal understanding of any of them...THEN?...Moulden tied it up...nicely. He and I discussed----GENE SHUNTS and ENZYME DERAILMENTS.....and we were UNAWARE that Protandim was already on the market....we simply did not know.
Here is an issue UNTOUCHED in this article...MAGNESIUM
a few years ago?...the HYPERSTERS tried to get everyone CONVINCED they could supplement with SAM-e.
IT DIDN'T work
IF the liver does not go through Methylation, Hydroxylation and glucaronidation?.....detoxification processes are NOT carried out
so...again....yes..I look STRONGLY at how to "modulate" the genome...into correct expression. OF about 400 "survivor gene expressions"...that get properly modulated?....they speak to roughly 8000 to 12,000 genes...all appropriately modulated then
it is NOT a stand alone....I also believe STRONGLY in monosacharide supplementation...
and ?...magnesium chloride, idoine, selenomethionine...baking soda....etc...
The MTHER gene MUST be associating with thousands of other gene expressions...and IF a series of or a significant number of genes are SHUNTED?....we have a failure to communicate Houston..
So...attempting to supplement with B3?....not fully effective...or B6 or B12..etc?..for mental function/cognition approaches.
and IF we're deficient proper nurition?.....say we're Eskimo....and we're being fed plant based foods?...we're going to MAGNIFY and COMPOUND the problems.
and?....age related gene expression must be addressed.
Some genes express in youth and infancy that DO NOT express in adolescence or adulthood...so that must be addressed.
We're being SHIFTED UNMERCIFULLY by hucksters...or?...by limited information from inside a community that is MISINFORMED.....which ALL of modern medicine qualifies for....as does ACADEMIA.
one thing that has been OMITTED?....over the last 40 years?...is glyphosate. From the beginning of the Viet Nam war?...until today?....we see the relationship of glyphosate contamination equal with the INCREASE of all autoimmune diseases..to include autism....
1st----the younger the easier and better and quicker.....PROTANDIM for every living soul on earth.
EVERYONE is deficient magnesium ...in chloride form
Detoxified iodine MUST be used....we're overloaded with fluoride, bromide, and chloride
selenomethionine supplemented with detoxified iodine?...A MERCURY MAGNET....but setting proper gene expression...so chelation and excretion processes are in place?...A MUST
and?....endogenous production of gluthione enzymes, catalase and SOD MUST be established.
otherwise?.....we'll be walking the dog
appropriate foods for our genetic makeup is a MUST also
we MUST NOT get caught up in this NOTION of genes are our future....and BAD GENES exist...(THAT IS WRONG)....genes express ..either appropriately or not
THIS Is why....this what glut does...
BUT NOT SUPPLEMENTED glut
BUT NOT SUPPLEMENTED glut..or IV
endogenously produced...but upregulation of the genes required for production
These are the 1st noticable responses by glut produced by our bodies...and autistic kids are deficient glut...because of GENE SHUNTS..
This one is NOT a protandim study...but looks at other MINOR "upregulator" process supplements:
http://www.sciencedirect.com/science/article/pii/S2213231713000645
Here is another one I like....but STILL not Protandim related....
http://www.hindawi.com/journals/omcl/2011/689524/
Here are 3 PubMed articles on the upregulation of Glut via Protandim:
http://www.ncbi.nlm.nih.gov/pubmed/?term=Protandim+and+glutathione
but do remember----it is NOT just glut that is crucial....ALL disease is rooted in free radical assault...resulting in oxidative stress....SO?....there must be a scavenger to reduce these assaults.....and that is where SOD comes into play
BUT?...the binding process is related to KEAP1...which is crucial in the Nrf2 protein that MUST enter the nucleus of every cell...to CLEAN THEM UP
this...the nucleus of every cell....?...is where the REAL WORK is performed
You can go to any health food store...purchase Atomidine and Selenomethionine
they are both available.....and will cost about $40.00 your first purchaasse...then.use bapproximatelly 300 mcg of the selenomethionine and 4 to 6 drops of the Atomidine
...daily
do the Atomindine FIRST thing in the morning...30 minutes away from any food....in CLEAN WATER ....about 4 to 6 oz water
NOW?...we need to pay EXTRA SPECIAL ATTENTION to how they...THEY are blocking the sun's frequencies...how they are damaging the water and the food and the soil...with ROUNDUP
----------
Here we have the FDA sticking their nose in everything again, and preventing people from really knowing what goes on with their health. Thus it is stated that you will need to get the test result interpreted by one of the sources that can interpret these tests. Oh yes and it states as well that the test requires first a doctors prescription, and while of course most pharma trained doctors are clueless about the MTHR defect. You know to actually figure out causation of any health situation, that does not fall under their parameters and of the scope of their practice. Prescribing drugs that fit a diagnosis that will pay under the insurance codes, oh that they can do, however. A profit sick system it is, in deed.
Status of our health-related genetic reports.
We no longer offer our health-related genetic reports to new customers to comply with the U.S. Food and Drug Administration’s directive to discontinue new consumer access during our regulatory review process.
At this time, we do not know the timeline as to which health reports might be available in the future or when they might be available.
https://www.23andme.com/health/
https://www.23andme.com/howitworks/
--------------
And how soon do you think Offit and the CDC will be onto addressing this information? They never will be because it still directly or at the least indirectly implicates as well, vaccines. This is actually the state of science that should exist, instead of the refusing to look outside the box that does exist.
The MTHFR Connection
http://mthfrliving.com/andreas-diary/mthfr-gene-mutation/
Autism, imprinting and epigenetic disorders: a metabolic syndrome linked to anomalies in homocysteine recycling starting in early life??
http://link.springer.com/article/10.1007%2Fs10815-011-9645-2
MTHFR-Genetics, Autism, and Disease
Aberrations in folate metabolic pathway and altered susceptibility to autism.
http://www.ncbi.nlm.nih.gov/pubmed/19440165
MTHFR gene mutation… What’s the big deal about Methylation?
http://doccarnahan.blogspot.com/2013/05/mthfr-gene-mutation-whats-big-deal.html
Autism Spectrum Disorder-associated Biomarkers for Case Evaluation and Management by Clinical Geneticists
Genetic abnormalities are common among ASDs. Therefore, it is important that affected families seek genetic counseling to determine the family risk of transmission of ASD-associated genes, as well as to provide insights into behavior modification in order to help reduce the impact of genetic polymorphisms.
http://www.medscape.com/viewarticle/584398_7
Common genetic polymorphisms can increase risk of autism spectrum disorders
The contribution of inheritance and genetic mutation versus environmental factors to the risk of ASD is hotly debated. Most twin studies show the contribution heavily tilted toward inheritance, but the exact amount of involvement of genes in ASD risk is less apparent. This is because, while the impact of rare genetic variations on ASD risk is becoming clear, the role of more common variations, so called single nucleotide polymorphisms (SNP), remains unresolved.
By analyzing one million of the common variations in each participant’s genome, it became clear that, in families where only one child is affected, 40% of the risk of ASD is inherited. In families where more than one child is affected this increased to over 60%. By looking in more detail at the unaffected parents and siblings of children with ASD it appeared that the inherited risk was additive.
http://www.news-medical.net/news/20121015/Common-genetic-polymorphisms-can-increase-risk-of-autism-spectrum-disorders.aspx
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How Vaccines Dysregulate The Immune System
http://gdsajj.wordpress.com/2011/08/05/how-vaccines-dysregulate-the-immune-system/
Vaccinations Cause Chronic Immune System Dysregulation
http://www.liveto110.com/vaccinations-cause-chronic-immune-system-dysregulation/
An Immune Disorder at the Root of Autism
So here’s the short of it: At least a subset of autism — perhaps one-third, and very likely more — looks like a type of inflammatory disease. And it begins in the womb. [No it does NOT, and that is not necessarily true, unless the mother has taken a Thimerosal containing flu vaccine, or such as an aluminum adjuvant containing DTaP vaccine. Much of this dysregulation can clearly happen after birth, and of course infants are vaccinated, from birth.]
It starts with what scientists call immune dysregulation. Ideally, your immune system should operate like an enlightened action hero, meting out inflammation precisely, accurately and with deadly force when necessary, but then quickly returning to a Zen-like calm. Doing so requires an optimal balance of pro- and anti-inflammatory muscle.
In autistic individuals, the immune system fails at this balancing act. Inflammatory signals dominate. Anti-inflammatory ones are inadequate. A state of chronic activation prevails. And the more skewed toward inflammation, the more acute the autistic symptoms.
Nowhere are the consequences of this dysregulation more evident than in the autistic brain. Spidery cells that help maintain neurons — called astroglia and microglia — are enlarged from chronic activation. Pro-inflammatory signaling molecules abound. Genes involved in inflammation are switched on.
These findings are important for many reasons, but perhaps the most noteworthy is that they provide evidence of an abnormal, continuing biological process. That means that there is finally a therapeutic target for a disorder defined by behavioral criteria like social impairments, difficulty communicating and repetitive behaviors.
http://www.nytimes.com/2012/08/26/opinion/sunday/immune-disorders-and-autism.html/?pagewanted=all&_r=0
A Mouse Model for the Immune Dysregulation Subtype of Autism, (And they would still claim to that there is no way vaccines have and can cause autism? That conclusion is of course clearly preposterous.)
http://tacanowblog.com/2012/07/23/a-mouse-model-for-the-immune-dysregulation-subtype-of-autism/
Vaccines and Autism, ADHD and Asthma
Immunizations and the Immunocompromised
"Yet, no doctor is trained to look for this type of immunodeficiency and/or the kind of immune dysregulation that multiple vaccine can cause; which lead to so called inflammatory syndromes and resulting overactivation of the brains microglia cells and resulting chronic levels of brain inflammation now ever more increasingly found in studies of those with autism. Vaccine aluminum adjuvants in several studies have been fund as well to in itself cause this stated inflammation.
http://www.epidemicanswers.org/vaccines-and-autism-adhd-and-asthma/
Immune Deficiencies
Antibodies (or Immunoglobins)
Concentrations of IL-12 and interferon gamma are much higher in the blood of children with autism than in normal children, indicating an immune activation, possibly due to adverse vaccine reactions. An optimal immune response to Candida infections necessitates a finely tuned balance of interferon gamma production; the dysregulation of the immune system, caused by IL-12-induced increases in gamma interferon, leads to increased Candida susceptibility in animals.
Read more:
http://www.greatplainslaboratory.com/home/eng/immunedeficiencies.asp
The immune response in autism: a new frontier for autism research
Immune aberrations consistent with a dysregulated immune response, which so far, have been reported in autistic children, include abnormal or skewed T helper cell type 1 (TH1)/TH2 cytokine profiles, decreased lymphocyte numbers, decreased T cell mitogen response, and the imbalance of serum immunoglobulin levels. In addition, autism has been linked with autoimmunity and an association with immune-based genes including human leukocyte antigen (HLA)-DRB1 and complement C4 alleles described.
Read more:
http://www.jleukbio.org/content/80/1/1.long
Study links vaccine induced immune overload to autism, diabetes, obesity
A new vaccine study published in Molecular and Genetic Medicine is bringing to the forefront the disturbing connection between the dramatic expansion in the quantity of routine childhood vaccines administered and a corresponding increase in inflammation-associated disorders.
Titled, "Review of Vaccine Induced Immune Overload and the Resulting Epidemics of Type 1 Diabetes and Metabolic Syndrome, Emphasis on Explaining the Recent Accelerations in the Risk of Prediabetes and other Immune Mediated Diseases," the study argues that vaccine-induced immune overload is a driving factor in a number of rapidly accelerating childhood epidemics including:
Autism
Type 1 diabetes
Asthma
Food allergies
Many autoimmune diseases
Obesity
Type 2 diabetes
Non-alcoholic fatty liver disease (NAFL)
Metabolic disease.
http://www.sott.net/article/279911-Study-links-vaccine-induced-immune-overload-to-autism-diabetes-obesity
http://www.organicconsumers.org/articles/article_30175.cfm
Review of Vaccine Induced Immune Overload and the Resulting Epidemics of Type 1 Diabetes and Metabolic Syndrome, Emphasis on Explaining the Recent Accelerations in the Risk of Prediabetes and other Immune Mediated Diseases
Abstract Background: Epidemics of type 1 diabetes had been linked to inflammation. Previous reports have suggested the prevalence of autism is increased in patients with type 1diabetes.
Methods: Medline and Google searches were performed in late 2010 to find a country where there was simulta-neous data on the incidence or prevalence of type 1 diabetes, type 2 diabetes and autism in multiple different races. The association between prevalence of autism in children and the incidence of type 1 diabetes or type 2 diabetes in children, when stratified by race, was studied.
Results: The prevalence of autism has a statistically significant positive association with the incidence of type 1 diabetes but has a statistically significant inverse association with type 2 diabetes.
Conclusion: This suggests that patients with autoimmune autism likely represent a large subset of patients with autism and that the etiology of the epidemic of autoimmune/inflammation mediated autism in children is likely to be related to the etiology of the simultaneous epidemic of type 1 diabetes in children.
http://www.omicsonline.com/open-access/vaccine-induced-immune-overload-and-the-resulting-epidemics-of-type-diabetes-and-metabolic-syndrome-1747-0862.S1-025.php?aid=24058
Autoimmune Disorders Caused by Vaccines
http://healthimpactnews.com/2012/autoimmune-disorders-caused-by-vaccines/
Self-Organized Criticality Theory of Autoimmunity
Conclusions/Significance
Systemic autoimmunity appears to be the inevitable consequence of over-stimulating the host's immune ‘system’ by repeated immunization with antigen, to the levels that surpass system's self-organized criticality.
http://www.plosone.org/article/info:doi%2F10.1371%2Fjournal.pone.0008382
How Do Vaccines Work? Immune Mechanisms and Consequences
http://pathwaystofamilywellness.org/component/option,com_crossjoomlaarticlemanager/Itemid,375/aid,1369/view,crossjoomlaarticlemanager/#sthash.rkJSugBv.dpuf
Your Immune System, How It Works And How Vaccines Damage It
http://www.vaccineriskawareness.com/Your-Immune-System-How-It-Works-And-How-Vaccines-Damage-It
Anatomy and Physiology of the Immune System, Part 4
How pharmaceuticals destroy nature
http://jonbarron.org/article/anatomy-and-physiology-immune-system-part-4#.UwH0pvldXbY
Understanding immunity requires more than immunology
http://www.nature.com/ni/journal/v11/n7/full/ni0710-561.html
Warning to Pregnant Mothers - Toxic Dose of Aluminum in the Tdap
Paul Thomas, Pediatrician
http://www.youtube.com/watch?v=VoY6vXEMsU8
Aluminum in Vaccines | A Pediatricians Warning To All Parents
http://www.youtube.com/watch?v=ee70I5bm3-k
Antibodies (or Immunoglobins)
The B-lymphocyte cells of the immune system produce antibodies called immunoglobulins. These antibodies are designed to react against specific antigens (or foreign molecules) introduced into the system by various types of microorganisms. Antibodies react against microorganisms (viruses, yeast, parasites, and bacteria) and allow them to be killed by the white blood cells. Composed mostly of amino acids, antibodies are proteins that are divided into five major antibody classes (IgM, IgG, IgE, IgA, IgD). Each antibody class has a unique chemical structure and a specific function. IgG stands for immunoglobulin G or antibody G and so forth. Each class contains thousands of different antibodies to different microorganisms, foods, and chemicals.
http://www.greatplainslaboratory.com/home/eng/immunedeficiencies.asp
As you can see, and for reasons noted here and due to inadequate detoxification ability; for those
MethylTetraHydroFolate Reductase Deficiency/Disorder, (MTHFR); vaccines would be obviously and highly contraindicated for use.
