High Levels of Aluminum Found in Autistic Children's Brain Tissue
Christopher Exley is one of the foremost experts on aluminum and aluminum toxicity within the human body. Listen as he explains and describes the results of his recent aluminum adjuvant related vaccine study with co-authors!!! The title of that study is: Aluminium in brain tissue in autism. https://www.sciencedirect.com/science/article/pii/S0946672X17308763
Aluminum, Interleukin-6, and Brain Inflammation
A central thesis of the Vaccine Papers blog is that aluminum adjuvant causes brain injury and autism by an immune activation mechanism. Specifically, the hypothesis is that aluminum adjuvant causes autism by inducing interleukin-6 (IL-6) production in the brain. Elevated IL-6 causes autism.
There is strong evidence for this hypothesis, but we do not yet have conclusive experimental results showing that Al adjuvant induces IL-6 (and/or IL-17a) in the brain. Instead we have experiments showing 1) soluble aluminum induces IL-6 in the brain and other tissues, and 2) Al adjuvant causes inflammation/microglial activation in the brain. Some of these studies use aluminum adjuvant dosages essentially the same as dosages infants receive according to the CDC schedule.
A Special Relationship Between Aluminum and IL-6?
Aluminum strongly induces IL-6, and there are good scientific reasons why. Aluminum causes oxidation, and IL-6 is produced in response to oxidative stress (e.g., low glutathione, elevated free radicals). IL-6 stimulates tissue repair and healing of oxidation injury.
One way aluminum likely induces oxidation is by displacing iron from a protein (transferrin) where iron is safely stored. Transferrin is specifically designed to bind iron and prevent it from causing oxidation. Free (unbound) iron floating around is very toxic, because its a potent catalyst for oxidation reactions. So, one way aluminum induces oxidation is by unleashing free iron. In living cells, free iron creates an explosion of destructive oxidation.
One way aluminum likely induces oxidation is by displacing iron from a protein (transferrin) where iron is safely stored. Transferrin is specifically designed to bind iron and prevent it from causing oxidation. Free (unbound) iron floating around is very toxic, because its a potent catalyst for oxidation reactions. So, one way aluminum induces oxidation is by unleashing free iron. In living cells, free iron creates an explosion of destructive oxidation.
The Viezeliene et al. paper (described below) states:
Read more:
http://vaccinepapers.org/aluminum-inflammation-interleukin-6/
New Kid On The Block: IL-17a
Click for list of papers in this post.
An important new paper (January 2016) by Choi et al. in the well-known journal Science provides valuable new information about how IL-6 causes autism. This paper reports that IL-6 causes autism by inducing production of the cytokine IL-17a.
Paper (Choi):The maternal interleukin-17a pathway in mice promotes autismlike phenotypes in offspring
In biochemistry and biology, there are “signalling pathways” that have multiple steps connected in a chain. There can be many steps in a signaling pathway. Cytokines often act this way. So, when we say that “IL-6 causes autism”, it could mean that IL-6 acts directly, or that the IL-6 triggers something else that causes autism.
The new discovery is that IL-17a acts downstream of IL-6 to cause autism. In other words, IL-17a production is an intermediate step between IL-6 production and autism. So, Choi et al provides both a confirmation and extension of IL-6-autism causality. No wonder this paper was published in one of the most important scientific journals in the world.
IL-17a is involved in autoimmune diseases, crohns disease, rheumatoid arthritis, multiple sclerosis and asthma for example. Its a really important cytokine associated with its own type of T-helper cell (Th17 cells). It was discovered in 1993. Here is a review paper on IL-17a: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2826676/
Choi et al. also performed a replication experiment demonstrating that maternal IL-6 injection causes autistic behavior in mice. So the IL-6-autism discovery has been replicated again.
Read more:
http://vaccinepapers.org/new-kid-block-il-17a/
Immunology. 2010 Mar
Interleukin-17 and its target genes: mechanisms of interleukin-17 function in disease
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2826676/
THE PRO-OXIDANT ACTIVITY OF ALUMINUM
CHRISTOPHER EXLEY
Birchall Centre for Inorganic Chemistry and Materials Science, Keele University, Staffordshire, UK
(Received 21 August 2003; Revised 17 November 2003; Accepted 20 November 2003)
Abstract—Aluminum, a non-redox-active metal is, nevertheless, a pro-oxidant both in in vitro preparations and in vivo.
It facilitates both superoxide- and iron-driven biological oxidation by mechanisms that remain to be resolved. More than
10 years ago Fridovich and colleagues suggested that the facilitation of superoxide-driven biological oxidation by
aluminum was due to an interaction between the metal and the superoxide radical anion (Free Radic. Biol. Med. 13:79 –
81; 1992). This thesis has been examined herein and it is concluded that much, if not all, of the pro-oxidant activity of
aluminum might be explained by the formation of an aluminum superoxide semireduced radical ion. D 2003 Elsevier
Inc.
http://vaccinepapers.org/wp-content/uploads/The-pro-oxidant-activity-of-aluminum.pdf
Vaccine Safety Conference Session 16 Dr. Christopher Exley
Dr. Christopher Exley- The Systemic Toxicity of Aluminium Adjuvants.
Dr. Christopher Exley is the Reader in Bioinorganic Chemistry at The Birchall Centre, Keele University in Staffordshire and Honorary Professor at the UHI Millennium Institute. Exley is a biologist (University of Stirling) with a PhD in the ecotoxicology of aluminium (University of Stirling). His research career (1984-present) has focused upon an intriguing paradox; 'how the third most abundant element of the Earth's crust (aluminium) is non-essential and largely inimical to life'. Investigating this mystery has required research in myriad fields from the basic inorganic chemistry of the reaction of aluminium and silicon to the potentially complex biological availability of aluminium in humans. Exley is also fascinated by the element silicon in relation to living things which, as the second most abundant element of the Earth's crust, is also almost devoid of biological function. One possible function of silicon is to keep aluminium out of biology (biota) and this area of study forms a large part of Exley's research.
(In the below video).
Christopher Exley is one of the foremost experts on aluminum and aluminum toxicity within the human body. Listen as he explains and describes the results of his recent aluminum adjuvant related vaccine study with co-authors!!! The title of that study is: Aluminium in brain tissue in autism. https://www.sciencedirect.com/science/article/pii/S0946672X17308763
Aluminum, Interleukin-6, and Brain Inflammation
A central thesis of the Vaccine Papers blog is that aluminum adjuvant causes brain injury and autism by an immune activation mechanism. Specifically, the hypothesis is that aluminum adjuvant causes autism by inducing interleukin-6 (IL-6) production in the brain. Elevated IL-6 causes autism.
There is strong evidence for this hypothesis, but we do not yet have conclusive experimental results showing that Al adjuvant induces IL-6 (and/or IL-17a) in the brain. Instead we have experiments showing 1) soluble aluminum induces IL-6 in the brain and other tissues, and 2) Al adjuvant causes inflammation/microglial activation in the brain. Some of these studies use aluminum adjuvant dosages essentially the same as dosages infants receive according to the CDC schedule.
A Special Relationship Between Aluminum and IL-6?
Aluminum strongly induces IL-6, and there are good scientific reasons why. Aluminum causes oxidation, and IL-6 is produced in response to oxidative stress (e.g., low glutathione, elevated free radicals). IL-6 stimulates tissue repair and healing of oxidation injury.
One way aluminum likely induces oxidation is by displacing iron from a protein (transferrin) where iron is safely stored. Transferrin is specifically designed to bind iron and prevent it from causing oxidation. Free (unbound) iron floating around is very toxic, because its a potent catalyst for oxidation reactions. So, one way aluminum induces oxidation is by unleashing free iron. In living cells, free iron creates an explosion of destructive oxidation.
One way aluminum likely induces oxidation is by displacing iron from a protein (transferrin) where iron is safely stored. Transferrin is specifically designed to bind iron and prevent it from causing oxidation. Free (unbound) iron floating around is very toxic, because its a potent catalyst for oxidation reactions. So, one way aluminum induces oxidation is by unleashing free iron. In living cells, free iron creates an explosion of destructive oxidation.
The Viezeliene et al. paper (described below) states:
Read more:
http://vaccinepapers.org/aluminum-inflammation-interleukin-6/
New Kid On The Block: IL-17a
Click for list of papers in this post.
An important new paper (January 2016) by Choi et al. in the well-known journal Science provides valuable new information about how IL-6 causes autism. This paper reports that IL-6 causes autism by inducing production of the cytokine IL-17a.
Paper (Choi):The maternal interleukin-17a pathway in mice promotes autismlike phenotypes in offspring
In biochemistry and biology, there are “signalling pathways” that have multiple steps connected in a chain. There can be many steps in a signaling pathway. Cytokines often act this way. So, when we say that “IL-6 causes autism”, it could mean that IL-6 acts directly, or that the IL-6 triggers something else that causes autism.
The new discovery is that IL-17a acts downstream of IL-6 to cause autism. In other words, IL-17a production is an intermediate step between IL-6 production and autism. So, Choi et al provides both a confirmation and extension of IL-6-autism causality. No wonder this paper was published in one of the most important scientific journals in the world.
IL-17a is involved in autoimmune diseases, crohns disease, rheumatoid arthritis, multiple sclerosis and asthma for example. Its a really important cytokine associated with its own type of T-helper cell (Th17 cells). It was discovered in 1993. Here is a review paper on IL-17a: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2826676/
Choi et al. also performed a replication experiment demonstrating that maternal IL-6 injection causes autistic behavior in mice. So the IL-6-autism discovery has been replicated again.
Read more:
http://vaccinepapers.org/new-kid-block-il-17a/
Immunology. 2010 Mar
Interleukin-17 and its target genes: mechanisms of interleukin-17 function in disease
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2826676/
THE PRO-OXIDANT ACTIVITY OF ALUMINUM
CHRISTOPHER EXLEY
Birchall Centre for Inorganic Chemistry and Materials Science, Keele University, Staffordshire, UK
(Received 21 August 2003; Revised 17 November 2003; Accepted 20 November 2003)
Abstract—Aluminum, a non-redox-active metal is, nevertheless, a pro-oxidant both in in vitro preparations and in vivo.
It facilitates both superoxide- and iron-driven biological oxidation by mechanisms that remain to be resolved. More than
10 years ago Fridovich and colleagues suggested that the facilitation of superoxide-driven biological oxidation by
aluminum was due to an interaction between the metal and the superoxide radical anion (Free Radic. Biol. Med. 13:79 –
81; 1992). This thesis has been examined herein and it is concluded that much, if not all, of the pro-oxidant activity of
aluminum might be explained by the formation of an aluminum superoxide semireduced radical ion. D 2003 Elsevier
Inc.
http://vaccinepapers.org/wp-content/uploads/The-pro-oxidant-activity-of-aluminum.pdf
Vaccine Safety Conference Session 16 Dr. Christopher Exley
Dr. Christopher Exley- The Systemic Toxicity of Aluminium Adjuvants.
Dr. Christopher Exley is the Reader in Bioinorganic Chemistry at The Birchall Centre, Keele University in Staffordshire and Honorary Professor at the UHI Millennium Institute. Exley is a biologist (University of Stirling) with a PhD in the ecotoxicology of aluminium (University of Stirling). His research career (1984-present) has focused upon an intriguing paradox; 'how the third most abundant element of the Earth's crust (aluminium) is non-essential and largely inimical to life'. Investigating this mystery has required research in myriad fields from the basic inorganic chemistry of the reaction of aluminium and silicon to the potentially complex biological availability of aluminium in humans. Exley is also fascinated by the element silicon in relation to living things which, as the second most abundant element of the Earth's crust, is also almost devoid of biological function. One possible function of silicon is to keep aluminium out of biology (biota) and this area of study forms a large part of Exley's research.
(In the below video).
Further information, in the above video.
Session 22, The Vaccine Safety Conference: Dr. Russell Blaylock, MD, CCN
THE CENTRAL ROLE OF IMMUNOEXCITOTOXICITY IN ALUMINUM AND MERCURY-CONTAINING ADJUVANT-TRIGGERED NEURODEVELOPMENTAL AND NEURODEGENERATIVE DISORDERS
Other Vaccine Safety Conference - Speakers
https://www.youtube.com/user/VaccineSafetyConf
Below, Dr Suzanne Humphries explains quite well the issue of Merck's dirty little secret, regarding vaccine aluminum adjuvants; listen closely, and all the way to the end of this informational video.
Session 22, The Vaccine Safety Conference: Dr. Russell Blaylock, MD, CCN
THE CENTRAL ROLE OF IMMUNOEXCITOTOXICITY IN ALUMINUM AND MERCURY-CONTAINING ADJUVANT-TRIGGERED NEURODEVELOPMENTAL AND NEURODEGENERATIVE DISORDERS
Other Vaccine Safety Conference - Speakers
https://www.youtube.com/user/VaccineSafetyConf
Below, Dr Suzanne Humphries explains quite well the issue of Merck's dirty little secret, regarding vaccine aluminum adjuvants; listen closely, and all the way to the end of this informational video.
High Levels of Aluminum Found in Autistic Children's Brain Tissue
To understand this horrendous situation and issue, you must first understand the available existing vaccine safety science, and as well the previous lack of any existing vaccine safety study science.
Study: Record Levels of Aluminum Found in Autistic Children Brain Tissue
November 28, 2017 4:04 pm
11-27-Aluminum_Featured_Image-300x156
Dr. Christopher Exley—one of the world’s leading experts on aluminum toxicity—has shown that chronic intoxication with myriad forms of this “ubiquitous and omnipresent metal” is exacting a high price on human health. Dr. Exley and other aluminum experts such as molecular biologist Dr. Lucija Tomljenovic have confirmed that aluminum readily and actively traverses the blood-brain barrier to selectively accumulate in brain tissues, where it induces unwelcome changes in brain biochemistry. As Dr. Exley has noted, “There are no ‘normal’ levels of brain aluminum,” meaning that “its presence in brain tissue, at any level, could be construed as abnormal” In light of the fact that even minute amounts of aluminum can have adverse neurological consequences, Dr. Exley’s newest paper—which reports on the first-ever study of aluminum in ASD brain tissue—is groundbreaking. Published in the Journal of Trace Elements in Medicine and Biology, the paper documents some of the highest values for aluminum in human brain tissue ever recorded. Using a two-pronged study design, the researchers measured and characterized aluminum deposits in brain tissues from five to ten ASD donors, most of whom died in their teens or twenties. What the research team found was startling. The study’s quantitative arm documented “consistently high” aluminum levels representing “some of the highest values for brain aluminum content ever measured in healthy or diseased tissues.”
Read More...
http://vaccineimpact.com/2017/study-record-levels-of-aluminum-found-in-autistic-children-brain-tissue/
Aluminium in brain tissue in autism
Abstract
Autism spectrum disorder is a neurodevelopmental disorder of unknown aetiology. It is suggested to involve both genetic susceptibility and environmental factors including in the latter environmental toxins. Human exposure to the environmental toxin aluminium has been linked, if tentatively, to autism spectrum disorder. Herein we have used transversely heated graphite furnace atomic absorption spectrometry to measure, for the first time, the aluminium content of brain tissue from donors with a diagnosis of autism. We have also used an aluminium-selective fluor to identify aluminium in braintissue using fluorescence microscopy. The aluminium content of brain tissue in autism was consistently high. The mean (standard deviation) aluminium content across all 5 individuals for each lobe were 3.82(5.42), 2.30(2.00), 2.79(4.05) and 3.82(5.17) μg/g dry wt. for the occipital, frontal, temporal and parietal lobes respectively. These are some of the highest values for aluminium in human brain tissueyet recorded and one has to question why, for example, the aluminium content of the occipital lobe of a 15 year old boy would be 8.74 (11.59) μg/g dry wt.? Aluminium-selective fluorescence microscopy was used to identify aluminium in brain tissue in 10 donors. While aluminium was imaged associated with neurones it appeared to be present intracellularly in microglia-like cells and other inflammatory non-neuronal cells in the meninges, vasculature, grey and white matter. The pre-eminence of intracellular aluminium associated with non-neuronal cells was a standout observation in autism brain tissueand may offer clues as to both the origin of the brain aluminium as well as a putative role in autism spectrum disorder.
https://www.sciencedirect.com/science/article/pii/S0946672X17308763
Full study: (scroll down on page)
https://ac.els-cdn.com/S0946672X17308763/1-s2.0-S0946672X17308763-main.pdf?_tid=f2be2fde-d56d-11e7-9e32-00000aab0f27&acdnat=1512005566_4d3d686804922e47e0b559810404e854
New Research Proves Brains of Children with Autism are Loaded with Aluminum
https://vactruth.com/2017/12/05/aluminum-and-autism/
How Vaccine Adjuvants Affect Your Brain
Dr. Mercola interviews Dr. Luciga Tomljenovic. She is a post-doctoral fellow at the University of British Columbia (UBC), where she works in neurosciences and the Department of Medicine.
Aluminum Adjuvants Are Falsely Assumed As Safe.
Rates of Autism Have Risen in Tandem with Vaccine Burden
Animal Study Demonstrates Harm of Aluminum Adjuvant
When You Alter Your Immune System, It Affects Your Brain Function
HPV Vaccine May Raise Your Risk of Autoimmune Disease
How Can Safety Be Proven When Proper Safety Studies Are Lacking and Health Statistics Indicate Otherwise?
Protect Your Right to Informed Consent and Defend Vaccine Exemptions
See, and read more:
https://articles.mercola.com/sites/articles/archive/2015/03/29/vaccine-adjuvants-brain-effects.aspx
New Study: 10x more aluminum in brains with autism
From our friends at the Children's Medical Safety Research Institute
Discovery of "Shockingly High" Levels of Aluminum in Brains of Individuals with Autism Suggests Link with Aluminum-Containing Vaccines
STAFFORDSHIRE, UNITED KINGDOM--(Marketwired - November 28, 2017) - A new study published in the Journal of Trace Elements in Medicine and Biology provides the strongest indication yet that aluminum is an etiological agent in autism spectrum disorder (ASD), according to researchers at Keele University in England.
The study used transversely heated graphite furnace atomic absorption spectrometry to measure, for the first time, the aluminum content of brain tissue from five donors who had died with diagnoses of ASD. The results showed the donors to have had some of the highest values of aluminum yet measured in human brain tissue.
The mean (standard deviation) aluminum content across all five individuals for each lobe were 3.82(5.42), 2.30(2.00), 2.79(4.05) and 3.82(5.17) mg/g dry wt. for the occipital, frontal, temporal and parietal lobes respectively. Previous measurements of 60 brains from humans not diagnosed with ASD showed an average content of 1 mg/g dry wt. of brain tissue.
"One has to wonder why aluminum in the occipital lobe of a 15-year-old boy with autism would be a value that is at least 10 times higher than what might be considered acceptable for an elderly adult?" said Christopher Exley PhD, Professor in Bioinorganic Chemistry and author of the study. Another ground-breaking study by Exley and his team, published earlier in the year, identified similarly high levels of aluminum in the brains of individuals who died of familial Alzheimer's disease.
While the aluminum content of each of the five brains was extraordinarily high, it was the location of the aluminum in the brain tissue that served as the standout observation. The majority of aluminum was identified inside non-neuronal cells including microglia and astrocytes. Aluminum was also found in lymphocytes in the meninges and in similar inflammatory cells in the vasculature. According to the researchers, there was clear evidence of inflammatory cells heavily loaded with aluminum entering the brain via the meningeal membranes and the blood-brain-barrier.
Aluminum-selective fluorescence microscopy was used to identify aluminum in the brain tissue of 10 donors. The results strongly suggest that aluminum is entering the brain in ASD via pro-inflammatory cells which have become loaded up with aluminum in the blood and/or lymph, much as has been demonstrated for monocytes at injection sites for vaccines including aluminum adjuvants.
The fact that the majority of aluminum found in brain tissues in ASD was intracellular and associated with non-neuronal cells is, at least for now, unique to ASD and may begin to explain why young adolescents had so much aluminum in their brains.
"The research does not infer that Al is a cause of autism, "said Exley, who also authored Human Exposure to Aluminum. "But these very high concentrations of a neurotoxin in brain tissue are not going to be benign and will contribute to neurodegeneration in affected tissues."
This study was funded by the Children's Medical Safety Research Institute, a 502(c)3 nonprofit organization dedicated to funding independent research into the causal factors behind today's epidemic of childhood chronic illness and disability.
Access to the full article here:
https://www.sciencedirect.com/science/article/pii/S0946672X17308763
Welcome to the Injecting Aluminum FREE 7 Day Replay event! The full feature film documentary is FREE to watch until December 14 at noon PST.
Spread the word about Aluminum in vaccines!
One of several presenters in this video series, "Mr. Aluminum", Dr. Christopher Exley, biologist at the University of Stirling with a PhD in the Ecotoxicology of Aluminum.
http://cinemalibrestudio.com/injecting-aluminum/IAevent.html
Injecting Aluminum | Trailer
https://vimeo.com/237018558
Injecting Aluminum
http://cinemalibrestudio.com/injecting-aluminum/index.html
Amount of aluminum in vaccines include: (per injected dose)
Hib (PedVaxHib brand only) - .225 mg per shot
Hepatitis B - .25 mg
DTaP - depending on the manufacturer, ranges from .17 to .625 mg
Pneumococcus - .125 mg
Hepatitis A - .25 mcg
HPV - .225 mg
Pentacel (DTaP, HIB and Polio combo vaccine) - .33 mcg
Pediarix (DTaP, Hep B and Polio combo vaccine) - .85 mcg
Dr. Exley on Vaccines, PhD in Ecotoxicology of Aluminum, University of Stirling
https://www.youtube.com/watch?v=il6wH81qHAo
Christopher Exley, more informational videos on aluminum toxicity.
https://www.youtube.com/results?search_query=Christopher+Exley+aluminum+study+
November 28, 2017 07:00 ET
Discovery of "Shockingly High" Levels of Aluminum in Brains of Individuals with Autism Suggests Link with Aluminum-Containing Vaccines
http://www.marketwired.com/press-release/discovery-shockingly-high-levels-aluminum-brains-individuals-with-autism-suggests-link-2241940.htm
Christopher Exley is one of the foremost experts on aluminum and aluminum toxicity within the human body. Listen as he explains and describes the results of his recent aluminum adjuvant related vaccine study, with co-authors!!!
https://www.youtube.com/watch?time_continue=6&v=SmkVv8pcVhc
Why Is Aluminum in Vaccines and Is It Safe?
Vaccines Damage Brain Function:
https://drjockers.com/why-is-aluminum-in-vaccines/
Pharmacol Toxicol. 1992 Apr;70(4):278-80.
Aluminium-adjuvanted vaccines transiently increase aluminium levels in murine brain tissue.
Redhead K1, Quinlan GJ, Das RG, Gutteridge JM.
Abstract
Aluminium is widely used as an adjuvant in human vaccines, and children can often receive up to 3.75 mg of parenteral aluminium during the first six months of life. We show that intraperitoneal injection of aluminium adsorbed vaccines into mice causes a transient rise in brain tissue aluminium levels peaking around the second and third day after injection. This rise is not seen in the saline control group of animals or with vaccine not containing aluminium. It is likely that aluminium is transported to the brain by the iron-binding protein transferrin and enters the brain via specific transferrin receptors.
https://www.ncbi.nlm.nih.gov/pubmed/1608913
Aluminum toxicity and astrocyte dysfunction: A metabolic link to neurological disorders
Abstract
Aluminum (Al) has been implicated in a variety of neurological diseases. However, the molecular mechanisms that enable Al to be involved in these disorders have yet to be fully delineated. Using astrocytes as a model of the cerebral cellular system, we have uncovered the biochemical networks that are affected by Al toxicity. In this review, we reveal how the inhibitory influence of Al on ATP production and on mitochondrial functions help generate globular astrocytes that are fat producing machines. These biological events may be the contributing factors to Al-triggered brain disorders.
http://www.sciencedirect.com/science/article/pii/S0162013411001814
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Follow up on the claim that no controls were used in the recent Exley and co-authors study.
Having provided and studied the brains from cadeavor controls with no diagnosed autism, and that been done in that study, or not; the point is here that normal levels of aluminum in the atypical/neurotypical brain, have clearly and previously been studied and determined. The most recent Exley study still remains as a damning commentary on the use of vaccine aluminum adjuvants. There is now a serious need to do further follow up studies. Will be hearing from the CDC or FDA on this issue, and as well as to the funding of follow up further studies? As always, likely not.
Brain. 1976 Mar;99(1):67-80.
Aluminium, neurofibrillary degeneration and Alzheimer's disease.
Crapper DR, Krishnan SS, Quittkat S.
Abstract
Aluminium is neurotoxic and results in the proliferation of 100 A diameter filaments in the cytoplasm of certain neurons. The aluminium concentration for 7 normal human brains was 1-9 +/- 0-7 SD mug/g dry weight (n = 208 samples). The aluminium content of 585 areas sampled in 10 post-mortem cases of Alzheimer's disease ranging in age from 50 to 88 years, in which the diagnosis was based on the specific histological appearances, revealed an elevated aluminium content in some regions. A range of 0-4 - 107-0 mug/g was encountered and 28 per cent of all regions sampled had concentrations in excess of 4 mug/g. Five of 6 cerebral biopsies from patients with Alzheimer's disease also had elevated aluminium content. In 2 additional Alzheimer's brains with neurofibrillary degeneration restricted to certain anatomical areas, elevated aluminium content was found to be associated with neurofibrillary degeneration and not with senile plaques. Furthermore, elevated aluminium content in multiple cortical regions was not found in 2 vascular dementias of the elderly. While the cytotoxic concentration for human neurons is unknown, the cytotoxic concentration for cat's cerebral neurons appears to lie between 4 and 6 mug/g dry weight.
https://www.ncbi.nlm.nih.gov/pubmed/963531
Aluminium in brain tissue in autism
Abstract
Autism spectrum disorder is a neurodevelopmental disorder of unknown aetiology. It is suggested to involve both genetic susceptibility and environmental factors including in the latter environmental toxins. Human exposure to the environmental toxin aluminium has been linked, if tentatively, to autism spectrum disorder. Herein we have used transversely heated graphite furnace atomic absorption spectrometry to measure, for the first time, the aluminium content of brain tissue from donors with a diagnosis of autism. We have also used an aluminium-selective fluor to identify aluminium in brain tissue using fluorescence microscopy. The aluminium content of brain tissue in autism was consistently high. The mean (standard deviation) aluminium content across all 5 individuals for each lobe were 3.82(5.42), 2.30(2.00), 2.79(4.05) and 3.82(5.17) μg/g dry wt. for the occipital, frontal, temporal and parietal lobes respectively. These are some of the highest values for aluminium in human brain tissue yet recorded and one has to question why, for example, the aluminium content of the occipital lobe of a 15 year old boy would be 8.74 (11.59) μg/g dry wt.? Aluminium-selective fluorescence microscopy was used to identify aluminium in brain tissue in 10 donors. While aluminium was imaged associated with neurones it appeared to be present intracellularly in microglia-like cells and other inflammatory non-neuronal cells in the meninges, vasculature, grey and white matter. The pre-eminence of intracellular aluminium associated with non-neuronal cells was a standout observation in autism brain tissue and may offer clues as to both the origin of the brain aluminium as well as a putative role in autism spectrum disorder.
3. Results
3.1. Aluminium content of brain tissues
The aluminium content of all tissues ranged from 0.01 (the limit of quantitation) to 22.11 μg/g dry wt. (Table 1). The aluminium content for whole brains (n = 4 or 5 depending upon the availability of hippocampus tissue) ranged from 1.20 (1.06) μg/g dry wt. for the 44 year old female donor (A1) to 4.77 (4.79) μg/g dry wt. for a 33 year old male donor (A5). Previous measurements of brain aluminium, including our 60 brain study [13], have allowed us to define loose categories of brain aluminium content beginning with ≤1.00 μg/g dry wt. as pathologically benign (as opposed to ‘normal’). Approximately 40% of tissues (24/59) had an aluminium content considered as pathologically-concerning (≥2.00 μg/g dry wt.) while approximately 67% of these tissues had an aluminium content considered as pathologically-significant (≥3.00 μg/g dry wt.). The brains of all 5 individuals had at least one tissue with a pathologically-significant content of aluminium. The brains of 4 individuals had at least one tissue with an aluminium content ≥5.00 μg/g dry wt. while 3 of these had at least one tissue with an aluminium content ≥10.00 μg/g dry wt. (Table 1). The mean (SD) aluminium content across all 5 individuals for each lobe were 3.82(5.42), 2.30(2.00), 2.79(4.05) and 3.82(5.17) μg/g dry wt. for the occipital, frontal, temporal and parietal lobes respectively. There were no statistically significant differences in aluminium content between any of the 4 lobes.
Read more:
https://www.sciencedirect.com/science/article/pii/S0946672X17308763
Exley's previous study.
Aluminium, iron and copper in human brain tissues donated to the
medical research council’s cognitive function and ageing study
Emily House,a Margaret Esiri,b Gill Forster,c Paul G Incec and
Christopher Exley*a Accepted 14th October 2011
Aluminium, iron and copper are all implicated in the aetiology of neurodegenerative diseases including Alzheimer’s disease. However, there are very few large cohort studies of the content of
these metals in aged human brains. We have used microwave digestion and TH GFAAS to measure aluminium, iron and copper in the temporal, frontal, occipital and parietal lobes of 60 brains donated to the Cognitive Function and Ageing Study. Every precaution was taken to reduce contamination of samples and acid digests to a minimum. Actual contamination was estimated by preparing a large number of (170+) method blanks which were interspersed within the full set of 700+ tissue digests. Subtraction of method blank values (MBV) from tissue digest values resulted in metal contents in all tissues in the range, MBV to 33 mg g1 dry wt. for aluminium, 112 to 8305 mg g1 dry wt. for iron and MBV to 384 mg g1 dry wt. for copper. While the median aluminium content for all tissues was 1.02 mg g1 dry wt. it was informative that 41 brains out of 60 included at least one tissue with an aluminium content which could be considered as potentially pathological (4 3.50 mg g1 dry wt.). The median content for iron was 286.16 mg g1 dry wt. and overall tissue iron contents were generally high which possibly reflected increased brain iron in ageing and in neurodegenerative disease. The median content for copper was 17.41 mg g1 dry wt. and overall tissue copper contents were lower than expected for aged brains but they were commensurate with aged brains showing signs of neurodegenerative disease. In this study we have shown, in particular, the value of carrying out significant numbers of method blanks to identify unknown sources of contamination. When these values are subtracted from tissue digest values the absolute metal contents could be considered as conservative and yet they may still reflect aspects of ageing and neurodegenerative disease in individual brains.
Read more:
https://pdfs.semanticscholar.org/cffe/16976a373a858d365a1d18d42bebb6d59181.pdf
https://www.ncbi.nlm.nih.gov/pubmed/22045115
---------------
BRAIN’S IMMUNE SYSTEM TRIGGERED IN AUTISM
http://www.hopkinsmedicine.org/Press_releases/2004/11_15a_04.html
Ann Neurol. 2005 Jan;57(1):67-81. Neuroglial activation and neuroinflammation in the brain of patients with autism. Vargas DL, Nascimbene C, Krishnan C, Zimmerman AW, Pardo CA.
Source: Department of Neurology, Johns Hopkins University School of Medicine, 600 North Wolfe Street, Baltimore, MD 21287, USA.
Abstract
Autism is a neurodevelopmental disorder characterized by impaired communication and social interaction and may be accompanied by mental retardation and epilepsy. Its cause remains unknown, despite evidence that genetic, environmental, and immunological factors may play a role in its pathogenesis. To investigate whether immune-mediated mechanisms are involved in the pathogenesis of autism, we used immunocytochemistry, cytokine protein arrays, and enzyme-linked immunosorbent assays to study brain tissues and cerebrospinal fluid (CSF) from autistic patients and determined the magnitude of neuroglial and inflammatory reactions and their cytokine expression profiles. Brain tissues from cerebellum, midfrontal, and cingulate gyrus obtained at autopsy from 11 patients with autismwere used for morphological studies. Fresh-frozen tissues available from seven patients and CSF from six living autistic patients were used for cytokine protein profiling. We demonstrate an active neuroinflammatory process in the cerebral cortex, white matter, and notably in cerebellum of autistic patients. Immunocytochemical studies showed marked activation of microglia and astroglia, and cytokine profiling indicated that macrophage chemoattractant protein (MCP)-1 and tumor growth factor-beta1, derived from neuroglia, were the most prevalent cytokines in brain tissues. CSF showed a unique proinflammatory profile of cytokines, including a marked increase in MCP-1. Our findings indicate that innate neuroimmune reactions play a pathogenic role in an undefined proportion of autistic patients, suggesting that future therapies might involve modifying neuroglial responses in the brain.
http://www.neuro.jhmi.edu/neuroimmunopath/pdf/4%20Neuroglial%20activation%20and%20neuroinflammation%20in%20the%20brain%20of%20patients%20with%20autism.pdf
http://www.ncbi.nlm.nih.gov/pubmed/15546155
January 2013
Microglial Activation in Young Adults With Autism Spectrum Disorder
Katsuaki Suzuki, MD, PhD; Genichi Sugihara, MD, PhD; Yasuomi Ouchi, MD, PhD; Kazuhiko Nakamura, MD, PhD;
Masami Futatsubashi, BS; Kiyokazu Takebayashi, MD, PhD; Yujiro Yoshihara, MD, PhD; Kei Omata, PhD;
Kaori Matsumoto, MA; Kenji J. Tsuchiya, MD, PhD; Yasuhide Iwata, MD, PhD; Masatsugu Tsujii, MA;
Toshirou Sugiyama, MD, PhD; Norio Mori, MD, PhD
Context: A growing body of evidence suggests that aberrant immunologic systems underlie the pathophysiologic characteristics of autism spectrum disorder (ASD). However, to our knowledge, no information is available on the patterns of distribution of microglial activation in the brain in ASD.
Conclusions: Our results indicate excessive microglial activation in multiple brain regions in young adult subjects with ASD. The similar distribution pattern of regional microglial activity in the ASD and control groups may indicate augmented but not altered microglial activation in the brain in the subjects with ASD.
In conclusion, the present PET measurements revealed marked activation of microglia in multiple brain regions of young adults with ASD. The results strongly support the contention that immune abnormalities contribute to the etiology of ASD. The similar patterns of distribution of regionally activated microglia in these ASD and control groups may indicate the augmented but not altered microglial activation in the brain in the ASD subjects.
https://vaccinepapers.org/wp-content/uploads/Microglial-activation-in-young-adults-with-autism-spectrum-disorder-1.pdf
Dr. Paul Offit’s Aluminum Deceptions and Academic Misconduct (one very important article, to read)
http://vaccinepapers.org/dr-paul-offits-aluminum-deceptions-academic-misconduct/
Paging Dr. Offit! Your Aluminum Neurotoxicity Reading Assignments Are Ready
https://jameslyonsweiler.com/2015/11/16/paging-dr-offit-your-aluminum-neurotoxicity-reading-assignments-are-ready/
Vaccine Papers
An Objective Look at Vaccine Dangers
https://vaccinepapers.org/
A Mechanism of Toxicity of Aluminium-based Adjuvants?
Consumer Summary | by Chris Exley
http://www.vaccinesafetyconference.com/exley
Aluminum as a Neurotoxin: The Evidence from Cell Culture, In Vivo, & Human Studies
http://www.vaccinesafetyconference.com/pdf/Shaw/Shaw_PPT.pdf
Aluminum Induced Immunoexcitotoxicity in Neurodevelopmental and Neurodegenerative Disorders
Russell L. Blaylock*
Visiting Professor Biology Belhaven University Theoretical Neurosciences Research, LLC Ridgeland, Mississippi, USA
Abstract
A great deal has been learned about the neurotoxicity of aluminum over the past two decades in terms of its ability to disrupt cellular function. Newer evidence suggests that a more central pathophysiological mechanism may be responsible for much of the toxicity of aluminum and aluminofluoride compounds on the brain. This mechanism involves activation of the brainâ € ™ s innate immune system, primarily the microglia, with a release of neurotoxic concentrations of excitotoxins and pro-inflammatory cytokines, chemokines and immune mediators. A large number of studies suggest that excitotoxicity plays a significant role in the neurotoxic action of a number of metals, including aluminum. Recently, researchers have found that while most of the chronic neurodegenerative effects of these metals are secondary to prolonged inflammation, it is the enhancement of excitotoxicity by the immune mediators that is responsible for most of the metalâ € ™ s toxicity. This enhancement occurs via a crosstalk between cytokine receptors and glutamate receptors. The author coined the name immunoexcitotoxicity to describe this process. This paper reviews the evidence linking immunoexcitotoxicity to aluminums neurotoxic effects.
http://www.geoengineeringwatch.org/documents/Aluminum-Blaylock.pdf
Autism Spectrum Disorders and Aluminum Vaccine Adjuvants
Lucija Tomljenovic, Russell L. Blaylock, Christopher A. Shaw
Abstract
Impaired brain function, excessive inflammation, and autoimmune manifestations are common in autism. Aluminum (Al), the most commonly used vaccine adjuvant, is a demonstrated neurotoxin and a strong immune stimulator. Hence, adjuvant Al has the necessary properties to induce neuroimmune disorders. Because peripheral immune stimuli in the postnatal period can compromise braindevelopment and cause permanent neurological impairments, the possibility that such outcomes could also occur with administration of Al vaccine adjuvants needs to be considered. In regard to the risk of adjuvant toxicity in children, the following should be noted: (i) children should not be viewed as “small adults” as their unique physiology makes them more vulnerable to toxic insults; (ii) in adult humans Al adjuvants can cause a variety of serious autoimmune and inflammatory conditions including those affecting the brain, yet children are routinely exposed to much higher amounts of Al from vaccines than adults; (iii) compelling evidence has underscored the tight connection between the development of the immune system and that of the brain. Thus, it appears plausible that disruptions of critical events in immune development may also play a role in the establishment of neurobehavioral disorders; (iv) the same immune system components that play key roles in brain development appear to be targeted for impairment by Al adjuvants. In summary, research data suggests that vaccines containing Al may be a contributing etiological factor in the increasing incidence of autism.
http://link.springer.com/referenceworkentry/10.1007%2F978-1-4614-4788-7_89
Review Article
Aluminum-Induced Entropy in Biological Systems:
Implications for Neurological Disease
http://people.csail.mit.edu/seneff/Shaw_et_al_JOT_2014.pdf
J Inorg Biochem. 2013 No;128:237-44. doi: 10.1016/j.jinorgbio.2013.07.022. Epub 2013 Jul 19.
Administration of aluminium to neonatal mice in vaccine-relevant amounts is associated with adverse long term neurological outcomes.
http://www.ncbi.nlm.nih.gov/pubmed/23932735
Journal of American Nutraceutical Association 6: 21-35, 2003.
Interaction of Cytokines, Excitotoxins, and Reactive Nitrogen and Oxygen Species in Autism Spectrum Disorders, Russell Blaylock, MD* Medical Director, Advanced Nutritional Concepts Ridgeland, Mississippi
http://www.nutrimedical.com/news.jhtml?method=view&news.id=1084
Clinical Features of Gulf War Syndrome and Autism
Russell L. Blaylock, M.D.
ABSTRACT
There is considerable and growing evidence that chronic microglial activation plays a major role in numerous neurological conditions including Alzheimer’s dementia, Parkinson’s disease,ALS, strokes, and inflammatory brain diseases. The release of toxic elements from activated microglia, such as cytokines and excitotoxins, is known to produce neurodegeneration. Peripheral immune stimulation has been shown to activate CNS microglia, and when excessive can lead to neurodegeneration and cognitive defects commonly associated with both the Gulf War Syndrome (GWS) and autism. This paper summarizes the mechanism linking these two disorders with excessive immune stimulation secondary to overvaccination.
http://www.jpands.org/vol9no2/blaylock.pd
Journal of Neuroimmunology
Immunological studies of cerebrospinal fluid from patients with CNS symptoms after human papillomavirus vaccination
http://www.jni-journal.com/article/S0165-5728(16)30154-0/abstract
How Vaccines Harm Child Brain Development - Dr Russell Blaylock MD
http://www.youtube.com/watch?v=7QBcMYqlaDs
Vaccines adversely effect the brain health of adults as well.
Vaccines, Depression and Neurodegeneration After Age 50 Years
https://heartmdinstitute.com/health-and-wellness/vaccines-depression-neurodegeneration-after-age-50-years/?showall=
The Danger of Excessive Vaccination During Brain Development, by Dr Russell Blaylock
http://articles.mercola.com/sites/articles/archive/2008/03/14/the-danger-of-excessive-vaccination-during-brain-development.aspx
Entropy 2012, 14(8), 1399-1442; doi:10.3390/e14081399
Review
The Initial Common Pathway of Inflammation, Disease, and Sudden Death
Robert M. Davidson 1,* and Stephanie Seneff
http://www.mdpi.com/1099-4300/14/8/1399
http://people.csail.mit.edu/seneff/Entropy/Entropy1_downloaded.pdf
Warning to Pregnant Mothers - Toxic Dose of Aluminum in the Tdap
https://www.youtube.com/watch?v=VoY6vXEMsU8
Warning to Pregnant Mothers- Toxic Dose of Aluminum in the Tdap
http://paulthomasmd.com/2012/12/11/warning-to-pregnant-mothers-toxic-dose-of-aluminum-in-the-tdap/
Aluminum in Vaccines | A Pediatricians Warning To All Parents
https://www.youtube.com/watch?v=ee70I5bm3-k
Slow CCL2-dependent translocation of biopersistent particles from muscle to brain
Conclusion
Nanomaterials can be transported by monocyte-lineage cells to DLNs, blood and spleen, and, similarly to HIV, may use CCL2-dependent mechanisms to penetrate the brain. This occurs at a very low rate in normal conditions explaining good overall tolerance of alum despite its strong neurotoxic potential. However, continuously escalating doses of this poorly biodegradable adjuvant in the population may become insidiously unsafe, especially in the case of overimmunization or immature/altered blood brain barrier or high constitutive CCL-2 production.
http://www.ncbi.nlm.nih.gov/pubmed/23557144
http://www.biomedcentral.com/1741-7015/11/99
Microglia in the developing brain: A potential target with lifetime effects
National Toxicology Program Laboratory, National Institute of Environmental Health Sciences, Research Triangle Park, NC, USA
http://www.sciencedirect.com/science/article/pii/S0161813X12000277
Cell Biology and Toxicology
April 2013, Volume 29, Issue 2, pp 75-84
How aluminum, an intracellular ROS generator promotes hepatic and neurological diseases: the metabolic tale
http://link.springer.com/article/10.1007%2Fs10565-013-9239-0
Mechanisms of aluminum adjuvant toxicity and autoimmunity in pediatric populations http://lup.sagepub.com/content/21/2/223.short http://www.ncbi.nlm.nih.gov/pubmed/22235057
Autoimmune or auto-inflammatory syndrome induced by adjuvants (ASIA):
Old truths and a new syndrome?
Pier Luigi Meroni a,b,*
http://xa.yimg.com/kq/groups/16063327/1870391070/name/ASIA3.pdf
Self-Organized Criticality Theory of Autoimmunity
Conclusions/Significance
Systemic autoimmunity appears to be the inevitable consequence of over-stimulating the host's immune ‘system’ by repeated immunization with antigen, to the levels that surpass system's self-organized criticality.
http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0008382 (Full study)
Vaccines and Brain Inflammation, Harold Buttram, MD , and Catherine Frompovich
http://www.vaccinationcouncil.org/2011/06/01/vaccines-and-brain-inflammation/
A Parent’s Primer: Vasculitis and Vaccines, (more inflammation problems, likely due to the aluminum adjuvants, this time its in the blood vessels)
http://sanevax.org/a-parents-primer-vasculitis-and-vaccines/
How the aluminum adjuvants cause this said inflammation. Follow closely.
J Immunol. 2008 Sep 15;181(6):3755-9. Cutting edge: alum adjuvant stimulates inflammatory dendritic cells through activation of the NALP3 inflammasome.
http://www.ncbi.nlm.nih.gov/pubmed/18768827
Hypothesis Neuro-inflammation, blood-brain barrier, seizures and autism
http://www.jneuroinflammation.com/content/8/1/168
Research The NALP3 inflammasome is involved in neurotoxic prion peptide-induced microglial activation
Abstract
Background
Prion diseases are neurodegenerative disorders characterized by the accumulation of an abnormal disease-associated prion protein, PrPSc. In prion-infected brains, activated microglia are often present in the vicinity of PrPSc aggregates, and microglial activation is thought to play a key role in the pathogenesis of prion diseases. Although interleukin (IL)-1β release by prion-induced microglia has been widely reported, the mechanism by which primed microglia become activated and secrete IL-1β in prion diseases has not yet been elucidated. In this study, we investigated the role of the NACHT, LRR and PYD domains-containing protein (NALP)3 inflammasome in IL-1β release from lipopolysaccharide (LPS)-primed microglia after exposure to a synthetic neurotoxic prion fragment (PrP106-126).
http://www.jneuroinflammation.com/content/9/1/73/abstract
Aluminum, Interleukin-6, and Brain Inflammation
How Aluminum Causes Autism
A Special Relationship Between Aluminum and IL-6?
http://vaccinepapers.org/aluminum-inflammation-interleukin-6/
New Kid On The Block: IL-17a
http://vaccinepapers.org/new-kid-block-il-17a/
THE PRO-OXIDANT ACTIVITY OF ALUMINUM
CHRISTOPHER EXLEY
http://vaccinepapers.org/wp-content/uploads/The-pro-oxidant-activity-of-aluminum.pdf
Debunking Aluminum Adjuvant, Part 2: FDA’s Flawed Study of Al Adjuvant Toxicity (The Mitkus study)
http://vaccinepapers.org/debunking-aluminum-adjuvant-part-2/
Clin Exp Rheumatol. 2015 Jul-Aug;33(4):545-8. Epub 2015 May 11.
Autoimmune/auto-inflammatory syndrome induced by adjuvants (ASIA) after quadrivalent human papillomavirus vaccination in Colombians: a call for personalised medicine.
Anaya JM1, Reyes B1, Perdomo-Arciniegas AM2, Camacho-Rodríguez B2, Rojas-Villarraga A1.
Abstract
This was a case study in which 3 patients with autoimmune/auto-inflammatory syndrome induced by adjuvants (ASIA) after quadrivalent human papillomavirus vaccination (HPV) were evaluated and described. All the patients were women. Diagnosis consisted of HLA-B27 enthesitis related arthritis, rheumatoid arthritis and systemic lupus erythematous, respectively. Our results highlight the risk of developing ASIA after HPV vaccination and may serve to increase the awareness of such a complication. Factors that are predictive of developing autoimmune diseases should be examined at the population level in order to establish preventive measures in at-risk individuals for whom healthcare should be personalized and participatory.
https://www.ncbi.nlm.nih.gov/pubmed/25962455
Aluminum Adjuvant Studies
http://medscienceresearch.com/aluminum/
Immunological studies of cerebrospinal fluid from patients with CNS symptoms after human papillomavirus vaccination
•32 patients with prolonged CNS symptoms after HPV vaccination were studied.
•CSF levels of IL-4, IL-13, IL-17, IL-8 and MCP-1 were elevated.
•CSF levels of PDGF-bb and IL-12 were decreased.
•Antibodies to GluN2B-NT2, GluN2B-CT and GluN1-NT in CSF were increased.
Abstract
In 32 patients with prolonged central nervous system symptoms after human papillomavirus (HPV) vaccination, we measured conventional and immunological markers in cerebrospinal fluid (CSF) and compared with the levels in disease controls. Our studies revealed significantly decreased chloride and neuron-specific enolase (NSE) levels in CSF of patients with CNS symptoms after HPV vaccination compared to disease controls. IL-4, IL-13, and CD4+ T cells increased significantly in patients, and IL-17 increased significantly from 12 to 24 months after symptom onset. Chemokines (IL-8 and MCP-1) were also elevated, but CD8+ T cells, PDGF-bb and IL-12 were reduced. Antibodies to GluN2B-NT2, GluN2B-CT and GluN1-NT increased significantly. These results suggest biological, mainly immunological, changes in the CSF of patients after HPV vaccination.
Authors: Yukitoshi Takahashi, Takashi Matsudaira, Hitoshi Nakano, Hirosato Nasu, Hitoshi Ikeda, Kentaro Nakaoka, Rumiko Takayama, Masayasu Oota
Read more:
http://sanevax.org/immunological-studies-cerebrospinal-fluid-patients-cns-symptoms-human-papillomavirus-vaccination/
And this is literally the tip of the iceberg regarding the existing evidence and the studies regarding Gardasil and Cervarix vaccine injury, and as well death. And now there is FDA approved additionally a Gardasil 9 with an increased dose of injected aluminum.The reason for that is the known existing issue of "original antigenic sin", and which only applies to injected vaccines; and that in regard to the additional strains of HPV included in that vaccine.
Gardasil-The Flagship Example of the Failure of Vaccine Authorities to Regulate and Assure Vaccine Safety - “HPV Vaccine Has Done This to My Child”
http://www.dirtybigpharmatruth.com/gardasil-the-flagship-example-of-the-failure-of-vaccine-authorities-to-regulate-and-assure-vaccine-safety.html
These stories and this kind of information regarding the vaccine caused injury and/or death of infants and small children, is everywhere, and if you actually took some time to look for it. The day of the CDC making denial of this, is over.
4 month vaccinations killed my baby
https://www.youtube.com/watch?v=SUMIWcqlfTw&t=650s
VAXXED TV - (source, packed with parental accounts of vaccine injury and death story videos; the same thing that pro-vaccinator's and the CDC would tell you, that it isn't happening and that it is all an unconnected coincidence regarding vaccines, and the massive vaccine schedule at the CDC that now exists).
https://www.youtube.com/channel/UCwZDSEpPvE398OLazdituKQ
-----------------
So here we have it, this is the study science that you need to directly follow to determine what is going on with vaccine aluminum adjuvants, and this is directly a recap and overview of that study science.
This is an existing scientific study documentation.
The subject matter here is aluminum adjuvants, resulting brain inflammation in autism, and as well the metallic debris which has as well now been found to exist in vaccines. As well is addressed the issue of polysorbate 80 in vaccines.
The pro-vax side demands that the entire picture of aluminum caused brain inflammation and resulting autism be covered and all of it, in one single study put in front of them. That is not and never has been how study science works. It is a scientific process of putting all of the study information, together.
This set of research studies directly show and prove beyond any reasonable doubt, that the aluminum in the brain found in Christopher Exley's recent study, is directly due to the use of vaccine aluminum adjuvants. Not only that but that-that said and injected aluminum is directly a cause of vaccine triggered autism.
Nanomolar aluminum induces pro-inflammatory and pro-apoptotic gene expression in human brain cells in primary culture
Walter J. Lukiw a,*, Maire E. Percy b, Theo P. Kruck b
Excerpt:
The promoters of genes up-regulated by aluminum are enriched in binding sites for the stress-inducible transcription factors HIF-1 and NF-kappaB, suggesting a role for aluminum, HIF-1 and NF-kappaB in driving atypical, pro-inflammatory and pro-apoptotic gene expression. The effect of aluminum on specific stress-related gene expression patterns in human brain cells clearly warrant further investigation.
http://www.sciencedirect.com/science/article/pii/S0162013405001182
http://www.ncbi.nlm.nih.gov/pubmed/15961160
Several sources have now studied the autistic brain and they have found chronic levels of brain inflammation in autistic brain study samples. The highest levels of brain tissue aluminum were recently found in the Exley and co-authors study, in those regions of the brain know as the microglia cells and areas that unatural aluminum would surely trigger over-activation and with resulting chronic levels of brain inflammation.
Lets not forget as well the recent Exley and co-authors study and which directly applies to the continued information and the studies that I have continued with below.
Study: Record Levels of Aluminum Found in Autistic Children Brain Tissue November 28, 2017
http://vaccineimpact.com/2017/study-record-levels-of-aluminum-found-in-autistic-children-brain-tissue/
Aluminium in brain tissue in autism
Matthew Molda, Dorcas Umarb, Andrew Kingc, Christopher Exleya,
a The Birchall Centre, Lennard-Jones Laboratories, Keele University, Staffordshire, ST5 5BG, United Kingdom
b Life Sciences, Keele University, Staffordshire, ST5 5BG, United Kingdom
c Department of Clinical Neuropathology, Kings College Hospital, London, SE5 9RS, United Kingdom
Abstract
Autism spectrum disorder is a neurodevelopmental disorder of unknown aetiology. It is suggested to involve both genetic susceptibility and environmental factors including in the latter environmental toxins. Human exposure to the environmental toxin aluminium has been linked, if tentatively, to autism spectrum disorder. Herein we have used transversely heated graphite furnace atomic absorption spectrometry to measure, for the first time, the aluminium content of brain tissue from donors with a diagnosis of autism. We have also used an aluminium-selective fluor to identify aluminium in braintissue using fluorescence microscopy. The aluminium content of brain tissue in autism was consistently high. The mean (standard deviation) aluminium content across all 5 individuals for each lobe were 3.82(5.42), 2.30(2.00), 2.79(4.05) and 3.82(5.17) μg/g dry wt. for the occipital, frontal, temporal and parietal lobes respectively. These are some of the highest values for aluminium in human brain tissueyet recorded and one has to question why, for example, the aluminium content of the occipital lobe of a 15 year old boy would be 8.74 (11.59) μg/g dry wt.? Aluminium-selective fluorescence microscopy was used to identify aluminium in brain tissue in 10 donors. While aluminium was imaged associated with neurones it appeared to be present intracellularly in microglia-like cells and other inflammatory non-neuronal cells in the meninges, vasculature, grey and white matter. The pre-eminence of intracellular aluminium associated with non-neuronal cells was a standout observation in autism brain tissueand may offer clues as to both the origin of the brain aluminium as well as a putative role in autism spectrum disorder.
https://www.sciencedirect.com/science/article/pii/S0946672X17308763
Full study: (scroll down on page)
https://ac.els-cdn.com/S0946672X17308763/1-s2.0-S0946672X17308763-main.pdf?_tid=f2be2fde-d56d-11e7-9e32-00000aab0f27&acdnat=1512005566_4d3d686804922e47e0b559810404e854
High Levels of Aluminum Found in Autistic Children's Brain Tissue
http://www.dirtybigpharmatruth.com/high-levels-of-aluminum-found-in-autistic-childrens-brain-tissue.html
Continued studies being done from now several sources have all found chronic levels of brain inflammation within the brain of those with autism. Those of course are donated brain, essentially autopsy studies. None of those studies have suggested a causation for what they term as an immune system triggered inflammatory syndrome. I suggest that the studies are more than now in, and directly showing that-that causation is indeed vaccines, and aluminum vaccine adjuvants.
BRAIN’S IMMUNE SYSTEM TRIGGERED IN AUTISM
http://www.hopkinsmedicine.org/Press_releases/2004/11_15a_04.html
Ann Neurol. 2005 Jan;57(1):67-81.
Neuroglial activation and neuroinflammation in the brain of patients with autism.
Vargas DL, Nascimbene C, Krishnan C, Zimmerman AW, Pardo CA.
Abstract
Autism is a neurodevelopmental disorder characterized by impaired communication and social interaction and may be accompanied by mental retardation and epilepsy. Its cause remains unknown, despite evidence that genetic, environmental, and immunological factors may play a role in its pathogenesis. To investigate whether immune-mediated mechanisms are involved in the pathogenesis of autism, we used immunocytochemistry, cytokine protein arrays, and enzyme-linked immunosorbent assays to study brain tissues and cerebrospinal fluid (CSF) from autistic patients and determined the magnitude of neuroglial and inflammatory reactions and their cytokine expression profiles. Brain tissues from cerebellum, midfrontal, and cingulate gyrus obtained at autopsy from 11 patients with autism were used for morphological studies. Fresh-frozen tissues available from seven patients and CSF from six living autistic patients were used for cytokine protein profiling. We demonstrate an active neuroinflammatory process in the cerebral cortex, white matter, and notably in cerebellum of autistic patients. Immunocytochemical studies showed marked activation of microglia and astroglia, and cytokine profiling indicated that macrophage chemoattractant protein (MCP)-1 and tumor growth factor-beta1, derived from neuroglia, were the most prevalent cytokines in brain tissues. CSF showed a unique proinflammatory profile of cytokines, including a marked increase in MCP-1. Our findings indicate that innate neuroimmune reactions play a pathogenic role in an undefined proportion of autistic patients, suggesting that future therapies might involve modifying neuroglial responses in the brain.
http://www.ncbi.nlm.nih.gov/pubmed/15546155
Full study:
http://citeseerx.ist.psu.edu/viewdoc/download?doi=10.1.1.512.6671&rep=rep1&type=pdf
Neuro-inflammation, blood-brain barrier, seizures and autism
Theoharis C Theoharides author and Bodi Zhang
http://jneuroinflammation.biomedcentral.com/articles/10.1186/1742-2094-8-168
Alum Activates the Bovine NLRP3 Inflammasome
https://www.frontiersin.org/articles/10.3389/fimmu.2017.01494/full
Journal of Neuroinflammation
The NALP3 inflammasome is involved in neurotoxic prion peptide-induced microglial activation
Results
We found that that PrP106-126-induced IL-1β release depends on NALP3 inflammasome activation, that inflammasome activation is required for the synthesis of pro-inflammatory and chemotactic factors by PrP106-126-activated microglia, that inhibition of NF-κB activation abrogated PrP106-126-induced NALP3 upregulation, and that potassium efflux and production of reactive oxygen species were implicated in PrP106-126-induced NALP3 inflammasome activation in microglia.
Conclusions
We conclude that the NALP3 inflammasome is involved in neurotoxic prion peptide-induced microglial activation. To our knowledge, this is the first time that strong evidence for the involvement of NALP3 inflammasome in prion-associated inflammation has been found.
Read more:
http://jneuroinflammation.biomedcentral.com/articles/10.1186/1742-2094-9-73
Going further into the study science here, In this below study we can easily see that these people know, and that they are intentionally designing adjuvants including aluminum adjuvants, to stimulate intracellular PRR, the NLRP3 inflammasome activity; and in apparently not realizing what is really going on regarding vaccine injuries and resulting autism. Modern medicine again yet obviously scientifically ignorant, of the complete picture of what takes place. Crazy as a pharma profit mad monkey, chasing its tail.
Inflammasome-activating nanoparticles as modular systems for optimizing vaccine efficacy. That is what aluminum adjuvants do.
Inflammasome-activating nanoparticles as modular systems for optimizing vaccine efficacy
Abstract
Innate immune system activation is a critical step in the initiation of an effective adaptive immune response; therefore, activation of a class of innate pathogen receptors called pattern recognition receptors (PRR) is a central feature of many adjuvant systems. It has recently been shown that one member of an intracellular PRR, the NLRP3 inflammasome, is activated by a number of classical adjuvants including aluminum hydroxide and saponins [Eisenbarth SC, Colegio OR, O’Connor W, Sutterwala FS, Flavell RA. Crucial role for the Nalp3 inflammasome in the immunostimulatory properties of aluminium adjuvants. Nature 2008;453(June (7198)):1122–6; Li H, Willingham SB, Ting JP, Re F. Cutting edge: inflammasome activation
by alum and alum’s adjuvant effect are mediated by NLRP3. J Immunol 2008;181(July (1)):17–21].
Inflammasome activation in vitro requires signaling of both the Toll-like receptor (TLR) and NLRP3 in antigen-presenting cells. Here we present a class of nanomaterials endowed with these two signals for rapid optimization of vaccine design. We constructed this system using a simple approach that incorporates lipopolysaccharides (LPS) onto the surface of nanoparticles constructed from a biocompatible polyester, poly(lactic-co-glycolic acid) (PLGA), loaded with antigen. We demonstrate that LPS-modified particles are preferentially internalized by dendritic cells compared to uncoated nanoparticles and the system, when administered to mice, elicits potent humoral and cellular immunity against a model antigen, ovalbumin. Wild-type macrophages pulsed with LPS-modified nanoparticles resulted in production of the proinflammatory cytokine IL-1 consistent with inflammasome activation. In comparison, NLRP3-deficient and caspase-1-deficient macrophages showed negligible production of IL-1. Furthermore, when endocytosis and lysosomal destabilization were inhibited, inflammasome activity was diminished, supporting the notion that nanoparticles rupture lysosomal compartments and behave as ‘danger signals’ [Hornung V, Bauernfeind F, Halle A, Samstad EO, Kono H, Rock KL, et al. Silica crystals and aluminum salts activate the NALP3 inflammasome through phagosomal destabilization. Nat Immunol 2008;9(August (8)):847–56].
The generality of this vaccination approach is tested by encapsulation of a recombinantWest Nile envelope protein and demonstrated by protection against a murine model of West Nile encephalitis. The design of such an antigen delivery mechanism with the ability to stimulate two potent innate immune pathways represents a potent new approach to simultaneous antigen and adjuvant delivery. © 2009 Elsevier Ltd.
Read more:
http://fahmylab.yale.edu/sites/default/files/files/Publications/2009/Demento2_2009.pdf
VaccinePapers.org - An objective look at vaccine dangers ...
(Take a look at the real vaccine study science, and what it shows, loads of data and research, right here).
http://vaccinepapers.org/
Identification of QS-21 as an Inflammasome-activating Molecular Component of Saponin Adjuvants*
http://www.jbc.org/content/291/3/1123.full
How Vaccine Adjuvants Affect Your Brain
Dr. Mercola interviews Dr. Luciga Tomljenovic. She is a post-doctoral fellow at the University of British Columbia (UBC), where she works in neurosciences and the Department of Medicine.
Aluminum Adjuvants Are Falsely Assumed As Safe.
Rates of Autism Have Risen in Tandem with Vaccine Burden
Animal Study Demonstrates Harm of Aluminum Adjuvant
When You Alter Your Immune System, It Affects Your Brain Function
HPV Vaccine May Raise Your Risk of Autoimmune Disease
How Can Safety Be Proven When Proper Safety Studies Are Lacking and Health Statistics Indicate Otherwise?
Protect Your Right to Informed Consent and Defend Vaccine Exemptions
See, and read more:
https://articles.mercola.com/sites/articles/archive/2015/03/29/vaccine-adjuvants-brain-effects.aspx
N Am J Med Sci. 2009 July; 1(2): 28–47.
What is regressive autism and why does it occur? Is it the consequence of multi-systemic dysfunction affecting the elimination of heavy metals and the ability to regulate neural temperature?
Graham E. Ewing
Abstract
There is a compelling argument that the occurrence of regressive autism is attributable to genetic and chromosomal abnormalities, arising from the overuse of vaccines, which subsequently affects the stability and function of the autonomic nervous system and physiological systems. That sense perception is linked to the autonomic nervous system and the function of the physiological systems enables us to examine the significance of autistic symptoms from a systemic perspective. Failure of the excretory system influences elimination of heavy metals and facilitates their accumulation and subsequent manifestation as neurotoxins: the long-term consequences of which would lead to neurodegeneration, cognitive and developmental problems. It may also influence regulation of neural hyperthermia. This article explores the issues and concludes that sensory dysfunction and systemic failure, manifested as autism, is the inevitable consequence arising from subtle DNA alteration and consequently from the overuse of vaccines.
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3364648/ (Full study)
Neuro-inflammation, blood-brain barrier, seizures and autism
Theoharis C TheoharidesEmail author and Bodi Zhang
Journal of Neuroinflammation20118:168
https://doi.org/10.1186/1742-2094-8-168© Theoharides and Zhang; licensee BioMed Central Ltd. 2011
Abstract
Many children with Autism Spectrum Diseases (ASD) present with seizure activity, but the pathogenesis is not understood. Recent evidence indicates that neuro-inflammation could contribute to seizures. We hypothesize that brain mast cell activation due to allergic, environmental and/or stress triggers could lead to focal disruption of the blood-brain barrier and neuro-inflammation, thus contributing to the development of seizures. Treating neuro-inflammation may be useful when anti-seizure medications are ineffective.
https://jneuroinflammation.biomedcentral.com/articles/10.1186/1742-2094-8-168
Research Article
The Severity of Autism Is Associated with Toxic Metal Body Burden and Red Blood Cell Glutathione Levels (same study)
J. B. Adams,1 M. Baral,2 E. Geis,3 J. Mitchell,1 J. Ingram,3 A. Hensley,3 I. Zappia,3 S. Newmark,4 E. Gehn,3 R. A. Rubin,5 K. Mitchell,3 J. Bradstreet,2,6 and J. M. El-Dahr7
Abstract
This study investigated the relationship of children's autism symptoms with their toxic metal body burden and red blood cell (RBC) glutathione levels. In children ages 3–8 years, the severity of autism was assessed using four tools: ADOS, PDD-BI, ATEC, and SAS. Toxic metal body burden was assessed by measuring urinary excretion of toxic metals, both before and after oral dimercaptosuccinic acid (DMSA). Multiple positive correlations were found between the severity of autism and the urinary excretion of toxic metals. Variations in the severity of autism measurements could be explained, in part, by regression analyses of urinary excretion of toxic metals before and after DMSA and the level of RBC glutathione (adjusted of 0.22–0.45, in all cases). This study demonstrates a significant positive association between the severity of autism and the relative body burden of toxic metals.
http://www.hindawi.com/journals/jt/2009/532640/ (full study)
Study: Evidence that Acetaminophen, Especially in Conjunction with Vaccines, is a Major Cause of Autism and Asthma
http://healthimpactnews.com/2013/study-evidence-that-acetaminophen-especially-in-conjunction-with-vaccines-is-a-major-cause-of-autism-and-asthma/
Autism Spectrum Disorders and Aluminum Vaccine Adjuvants
Lucija Tomljenovic, Russell L. Blaylock, Christopher A. Shaw
Abstract
Impaired brain function, excessive inflammation, and autoimmune manifestations are common in autism. Aluminum (Al), the most commonly used vaccine adjuvant, is a demonstrated neurotoxin and a strong immune stimulator. Hence, adjuvant Al has the necessary properties to induce neuroimmune disorders. Because peripheral immune stimuli in the postnatal period can compromise brain development and cause permanent neurological impairments, the possibility that such outcomes could also occur with administration of Al vaccine adjuvants needs to be considered. In regard to the risk of adjuvant toxicity in children, the following should be noted: (i) children should not be viewed as “small adults” as their unique physiology makes them more vulnerable to toxic insults; (ii) in adult humans Al adjuvants can cause a variety of serious autoimmune and inflammatory conditions including those affecting the brain, yet children are routinely exposed to much higher amounts of Al from vaccines than adults; (iii) compelling evidence has underscored the tight connection between the development of the immune system and that of the brain. Thus, it appears plausible that disruptions of critical events in immune development may also play a role in the establishment of neurobehavioral disorders; (iv) the same immune system components that play key roles in brain development appear to be targeted for impairment by Al adjuvants. In summary, research data suggests that vaccines containing Al may be a contributing etiological factor in the increasing incidence of autism.
http://link.springer.com/referenceworkentry/10.1007%2F978-1-4614-4788-7_89
Polysorbate 80 in vaccines as well helps open the blood/brain barrier making it easier for toxic metals in vaccines and as well inflammation causing aluminum adjuvants and other metals to pass through.
Big Pharma’s Dirty Little Secret: Vaccine-Induced Autoimmune Injury
https://www.healthnutnews.com/big-pharmas-dirty-little-secret-vaccine-induced-autoimmune-injury/
Nanoparticles enhance brain delivery of blood–brain barrier-impermeable probes for in vivo optical and magnetic resonance imaging
Abstract
Several imaging modalities are suitable for in vivo molecular neuroimaging, but the blood–brain barrier (BBB) limits their utility by preventing brain delivery of most targeted molecular probes. We prepared biodegradable nanocarrier systems made up of poly(n-butyl cyanoacrylate) dextran polymers coated with polysorbate 80 (PBCA nanoparticles) to deliver BBB-impermeable molecular imaging probes into the brain for targeted molecular neuroimaging. We demonstrate that PBCA nanoparticles allow in vivo targeting of BBB-impermeable contrast agents and staining reagents for electron microscopy, optical imaging (multiphoton), and whole brain magnetic resonance imaging (MRI), facilitating molecular studies ranging from individual synapses to the entire brain. PBCA nanoparticles can deliver BBB-impermeable targeted fluorophores of a wide range of sizes: from 500-Da targeted polar molecules to 150,000-Da tagged immunoglobulins into the brain of living mice. The utility of this approach is demonstrated by (i) development of a “Nissl stain” contrast agent for cellular imaging, (ii) visualization of amyloid plaques in vivo in a mouse model of Alzheimer's disease using (traditionally) non–BBB-permeable reagents that detect plaques, and (iii) delivery of gadolinium-based contrast agents into the brain of mice for in vivo whole brain MRI. Four-dimensional real-time two-photon and MR imaging reveal that brain penetration of PBCA nanoparticles occurs rapidly with a time constant of ∼18 min. PBCA nanoparticles do not induce nonspecific BBB disruption, but collaborate with plasma apolipoprotein E to facilitate BBB crossing. Collectively, these findings highlight the potential of using biodegradable nanocarrier systems to deliver BBB-impermeable targeted molecular probes into the brain for diagnostic neuroimaging.
http://www.pnas.org/content/108/46/18837.full
Polysorbate 80: A Risky Vaccine Ingredient (lots of direct info)
https://healthimpactnews.com/2016/polysorbate-80-a-risky-vaccine-ingredient/
Why wasn't this important study in any of pharma journal, or the study ever addressed at the CDC?
Food Chem Toxicol. 1993 Mar;31(3):183-90.
Delayed effects of neonatal exposure to Tween 80 on female reproductive organs in rats.
Gajdová M1, Jakubovsky J, Války J.
Abstract
Neonatal female rats were injected ip (0.1 ml/rat) with Tween 80 in 1, 5 or 10% aqueous solution on days 4-7 after birth. Treatment with Tween 80 accelerated maturation, prolonged the oestrus cycle, and induced persistent vaginal oestrus. The relative weight of the uterus and ovaries was decreased relative to the untreated controls. Squamous cell metaplasia of the epithelial lining of the uterus and cytological changes in the uterus were indicative of chronic oestrogenic stimulation. Ovaries were without corpora lutea, and had degenerative follicles.
https://www.ncbi.nlm.nih.gov/pubmed/8473002?dopt=Abstract
Concerns on Using Polysorbate 80 in Vaccines
Immunocontraceptive
Here’s a strange one -
A patent for a vaccine that would decrease the ability for fertility in animals (which can be found here -submitted by the University
of Georgia Research Foundation) “preferably includes Tween 80 (Polysobate 80)”. [3]
The patent immediately goes on to site the book “The Theory and Practical Application of Adjuvants” after declaring Tween 80 as a preferable ingredient. This book lists the benefits and pitfalls associated with the use of different adjuvants. Studies include such problems as isolation, adverse reactions and practical applications.[3][4]
At least there is a practical application for it - decreasing fertility?!
Read more:
http://blindedbythelightt.blogspot.com/2012/05/concerns-on-using-polysorbate-80-in.html
1. (WO1999034825) FERTILITY IMPAIRING VACCINE AND METHOD OF USE
https://patentscope.wipo.int/search/en/detail.jsf?docId=WO1999034825
Here is the said and so called Adams study. What is the source of those excessive levels of metals? The below this study links will show that source has been directly found to be, vaccines.
Biol Trace Elem Res. 2013 Feb;151(2):171-80. doi: 10.1007/s12011-012-9551-1. Epub 2012 Nov 29.
Toxicological status of children with autism vs. neurotypical children and the association with autism severity.
Adams JB, Audhya T, McDonough-Means S, Rubin RA, Quig D, Geis E, Gehn E, Loresto M, Mitchell J, Atwood S, Barnhouse S, Lee W.
Abstract
This study investigates both the level of toxic metals in children with autism and the possible association of those toxic metals with autism severity. This study involved 55 children with autism ages 5-16 years compared to 44 controls with similar age and gender. The study included measurements of toxic metals in whole blood, red blood cells (RBC), and urine. The autism group had higher levels of lead in RBC (+41 %, p = 0.002) and higher urinary levels of lead (+74 %, p = 0.02), thallium (+77 %, p = 0.0001), tin (+115 %, p = 0.01), and tungsten (+44 %, p = 0.00005). However, the autism group had slightly lower levels of cadmium in whole blood (-19 %, p = 0.003). A stepwise, multiple linear regression analysis found a strong association of levels of toxic metals with variation in the degree of severity of autism for all the severity scales (adjusted R(2) of 0.38-0.47, p < 0.0003). Cadmium (whole blood) and mercury (whole blood and RBC) were the most consistently significant variables. Overall, children with autism have higher average levels of several toxic metals, and levels of several toxic metals are strongly associated with variations in the severity of autism for all three of the autism severity scales investigated.
http://www.ncbi.nlm.nih.gov/pubmed/23192845
Evidence of oxidative damage and inflammation associated with low glutathione redox status in the autism brain
S Rose1, S Melnyk1, O Pavliv1, S Bai1, T G Nick1, R E Frye1 and S J James1
1Department of Pediatrics, University of Arkansas for Medical Sciences, Arkansas Children's Hospital Research Institute, Little Rock, AR, USA
Accepted 31 May 2012
Abstract
Despite increasing evidence of oxidative stress in the pathophysiology of autism, most studies have not evaluated biomarkers within specific brain regions, and the functional consequences of oxidative stress remain relatively understudied. We examined frozen samples from the cerebellum and temporal cortex (Brodmann area 22 (BA22)) from individuals with autism and unaffected controls (n=15 and n=12 per group, respectively). Biomarkers of oxidative stress, including reduced glutathione (GSH), oxidized glutathione (GSSG) and glutathione redox/antioxidant capacity (GSH/GSSG), were measured. Biomarkers of oxidative protein damage (3-nitrotyrosine; 3-NT) and oxidative DNA damage (8-oxo-deoxyguanosine; 8-oxo-dG) were also assessed. Functional indicators of oxidative stress included relative levels of 3-chlorotyrosine (3-CT), an established biomarker of a chronic inflammatory response, and aconitase activity, a biomarker of mitochondrial superoxide production. Consistent with previous studies on plasma and immune cells, GSH and GSH/GSSG were significantly decreased in both autism cerebellum (P<0.01) and BA22 (P<0.01). There was a significant increase in 3-NT in the autism cerebellum and BA22 (P<0.01). Similarly, 8-oxo-dG was significantly increased in autism cerebellum and BA22 (P<0.01 and P=0.01, respectively), and was inversely correlated with GSH/GSSG in the cerebellum (P<0.01). There was a significant increase in 3-CT levels in both brain regions (P<0.01), whereas aconitase activity was significantly decreased in autism cerebellum (P<0.01), and was negatively correlated with GSH/GSSG (P=0.01). Together, these results indicate that decreased GSH/GSSG redox/antioxidant capacity and increased oxidative stress in the autism brain may have functional consequence in terms of a chronic inflammatory response, increased mitochondrial superoxide production, and oxidative protein and DNA damage.
http://www.nature.com/tp/journal/v2/n7/full/tp201261a.html
April 25, 2017
Study: Almost All Vaccines Contaminated with Toxins and Linked to Side Effects
http://vaccineimpact.com/2017/study-almost-all-vaccines-contaminated-with-toxins-and-linked-to-side-effects/
Breaking Interview: Lead Author of 'Dirty Vaccines' Study Speaks Out
http://www.greenmedinfo.com/blog/breaking-interview-lead-author-dirty-vaccines-study-speaks-out
New Quality-Control Investigations on Vaccines: Micro- and Nanocontamination
http://medcraveonline.com/IJVV/IJVV-04-00072.pdf
Dirty Vaccines: New Study Reveals Prevalence of Contaminants
Every Human Vaccine Tested Was Contaminated by Unsafe Levels of Metals and Debris Linked to Cancer and Autoimmune Disease, New Study Reports
Researchers examining 44 samples of 30 different vaccines found dangerous contaminants, including red blood cells in one vaccine and metal toxicants in every single sample tested – except in one animal vaccine.
Using extremely sensitive new technologies not used in vaccine manufacturing, Italian scientists reported they were “baffled” by their discoveries which included single particles and aggregates of organic debris including red cells of human or possibly animal origin and metals including lead, tungsten, gold, and chromium, that have been linked to autoimmune disease and leukemia.
In the study, published this week in the International Journal of Vaccines and Vaccination, the researchers led by Antonietta Gatti, of the National Council of Research of Italy and the Scientific Director of Nanodiagnostics, say their results “show the presence of micro- and nano-sized particulate matter composed of inorganic elements in vaccine samples” not declared in the products’ ingredients lists.
Lead particles were found in the cervical cancer vaccines, Gardasil and Cervarix, for example, and in the seasonal flu vaccine Aggripal manufactured by Novartis as well as in the Meningetec vaccine meant to protect against meningitis C.
Samples of an infant vaccine called Infarix Hexa (against diphtheria, tetanus, pertussis, hepatitis B, poliomyelitis and haemophilus influenzae type B) manufactured by GlaxoSmithKline was found to contain stainless steel, tungsten and a gold-zinc aggregate.
Other metal contaminants included platinum, silver, bismuth, iron, and chromium. Chromium (alone or in alloy with iron and nickel) was identified in 25 of the human vaccines from Italy and France that were tested.
GSK’s Fluarix vaccine for children three years and older contained 11 metals and aggregates of metals. Similar aggregates to those identified in the vaccines have been shown to be prevalent in cases of leukemia, the researchers noted.
Many of the vaccines contained iron and iron alloys which, according to the researchers, “can corrode and the corrosion products exert a toxicity affecting the tissues”.
READ MORE:
http://info.cmsri.org/the-driven-researcher-blog/dirty-vaccines-new-study-reveals-prevalence-of-contaminants
Part 1: Dirty Vaccines: Every Human Vaccine Tested Was Contaminated With Metals and Debris in New Study
http://www.greenmedinfo.com/blog/dirty-vaccines-every-human-vaccine-tested-was-contaminated-metals-and-debris-new-
Dirty Vaccines – Part Two: What the Industry Knows and Isn't Telling You
http://www.greenmedinfo.com/blog/dirty-vaccines-part-two-what-industry-knows-and-isnt-telling-you
Polysorbate 80 in vaccines as well helps open the blood/brain barrier making it easier for toxic metals in vaccines and as well inflammation causing aluminum adjuvants to pass through.
Metals Debris Found in Vaccine Supply
http://www.ecowatch.com/kennedy-metal-debris-vaccines-2276687112.html
HEALTH AND WELLNESS
GROUNDBREAKING RESEARCH LINKS AUTISM WITH HISTAMINE, INFLAMMATION AND MAST CELL ACTIVATION
APRIL 15, 2017 OPENHEARTED REBEL 6 COMMENTS
By Carolanne Wright, Wake Up World
https://openheartedrebel.com/2017/04/15/groundbreaking-research-autism-histamine-inflammation-mast-cell-activation/
The Impacts of Vaccines: Aluminum, Autoimmunity, Autism and Alzheimer’s
Rebutting Big Pharma’s Talking Points About the Safety of Aluminum (and Mercury) in Vaccines
By Dr. Gary G. Kohls
Global Research, March 16, 2017
http://www.globalresearch.ca/the-impacts-of-vaccines-aluminum-autoimmunity-autism-and-alzheimers/
----------------
The real answers as to vaccine injury have been there all along. Answers that the CDC and the pro-vaccinator's, refuse to see and to acknowledge.
The late, Dr Andrew Moulden.
Dr. Andrew Moulden: Learning to Identify Vaccine Damage
https://vaccineimpact.com/2015/dr-andrew-moulden-learning-to-identify-vaccine-damage/
Dr. Andrew Moulden's Tolerance Lost: Part 1 - "The Problem"
https://www.youtube.com/watch?v=Re8UI8aCLpM
Tolerance Lost Vol 1/3 - 1 of 16 - Moulden
https://www.youtube.com/watch?v=RZXM-TKvLN8
Health Canada Corruption - Dr. Andrew Moulden
Dr. Andrew Moulden getting the message of truth out to people about the extreme corporate corruption of Health Canada, the FDA, and other corporate controlled medical care entities that are, in fact, destroying peoples health with vaccines and other chemical pharmaceutical drugs.
https://www.dailymotion.com/video/xbo5vf
Are You Crooked? (Forrest Maready)
https://www.youtube.com/watch?v=4lf8fdiU1Qk
ARE YOU CROOKED?
What our faces are trying to tell us.
http://areyoucrooked.com/
---------------
Proof as well that vaccines, and particularly vaccine aluminum adjuvants can cause excessive immune system reactivity that can harm an unborn infant.
Flu vaccines and regardless of containing Thimerosal, and as well the aluminum adjuvant containing Dtap vaccine, are CDC recommended for all pregnant women.
Now lets look at some study science that the CDC is obviously ignoring. Be sure to follow this all the way to the end.
Maternal immune activation yields offspring displaying mouse versions of the three core symptoms of autism
Natalia V. Malkova*, Collin Z. Yu, Elaine Y. Hsiao, Marlyn J. Moore, and Paul H. Patterson
Biology Division, California Institute of Technology, Pasadena, CA 91125
Abstract
The core symptoms of autism are deficits in social interaction and language, and the presence of repetitive/stereotyped behaviors. We demonstrate that behaviors related to these symptoms are present in a mouse model of an environmental risk factor for autism, maternal infection. We stimulate the maternal immune system by injecting the viral mimic poly(I:C) during pregnancy, and analyze the social and communicative behaviors of the offspring. In one test, young pups respond to a brief separation from the mother with ultrasonic vocalizations (USVs). We find that, compared to pups born to saline-injected mothers, pups born to maternal immune activation (MIA) mothers produce a lower rate of USVs in the isolation test starting at day 8. The quality of the vocalizations is also different; analysis of sound spectrograms of ten day-old pups shows that male pups from MIA mothers emit significantly fewer harmonic and more complex and short syllables. These communication differences are also apparent in adult offspring. Compared to controls, adult MIA males emit significantly fewer USVs in response to social encounters with females or males, and display reduced scent marking in response to female urine. Regarding a second autism symptom, MIA males display decreased sociability. In a third test of characteristic autism behaviors, MIA offspring exhibit increased repetitive/stereotyped behavior in both marble burying and self-grooming tests. In sum, these results indicate that MIA yields male offspring with deficient social and communicative behavior, as well as high levels of repetitive behaviors, all of which are hallmarks of autism.
http://vaccinepapers.org/wp-content/uploads/Maternal-immune-activation-yields-offspring-displaying-mouse-versions-of-the-three-core-symptoms-of-autism.pdf
Here below is the current CDC vaccine schedule for pregnant women.
Influenza (Inactivated)
Tdap
Guidelines for Vaccinating Pregnant Women
https://www.cdc.gov/vaccines/pregnancy/hcp/guidelines.html
https://www.cdc.gov/vaccines/acip/committee/guidance/rec-vac-preg.html
Did Chinese scientists find autism’s missing puzzle piece?
BY J.B. HANDLEY February 22, 2017
Discovery #1: “Maternal Immune Activation” can cause autism
Discovery #2: Aluminum Adjuvant causes immune activation and is far more neurotoxic than previously thought
Discovery #3: Aluminum can increase IL-6 in the brain
The evidence for post-natal autism triggers is strong
Discovery #4: Hepatitis B vaccine induces IL-6 in postnatal rats
https://healthcareinamerica.us/did-chinese-scientists-find-autisms-missing-puzzle-piece-2d50be5b9122
Warning to Pregnant Mothers - Toxic Dose of Aluminum in the Tdap
by Paul Thomas, Pediatrician
https://www.youtube.com/watch?v=VoY6vXEMsU8
Non-linear dose-response of aluminium hydroxide adjuvant particles: Selective low dose neurotoxicity
A B S T R A C T
Aluminium (Al) oxyhydroxide (Alhydrogel1), the main adjuvant licensed for human and animal vaccines, consists of primary nanoparticles that spontaneously agglomerate. Concerns about its safety emerged following recognition of its unexpectedly long-lasting biopersistence within immune cells in some individuals, and reports of chronic fatigue syndrome, cognitive dysfunction, myalgia, dysautonomia and autoimmune/inflammatory features temporally linked to multiple Al-containing vaccine administrations. Mouse experiments have documented its capture and slow transportation by monocyte-lineage cells from the injected muscle to lymphoid organs and eventually the brain. The present study aimed at evaluating mouse brain function and Al concentration 180 days after injection of various doses of Alhydrogel1 (200, 400 and 800mg Al/kg of body weight) in the tibialis anterior muscle in adult female CD1 mice. Cognitive and motor performances were assessed by 8 validated tests, microglial activation by Iba-1 immunohistochemistry, and Al level by graphite furnace atomic absorption spectroscopy.
An unusual neuro-toxicological pattern limited to a low dose of Alhydrogel1 was observed. Neurobehavioural changes, including decreased activity levels and altered anxiety-like behaviour, were
observed compared to controls in animals exposed to 200mg Al/kg but not at 400 and 800mg Al/kg. Consistently, microglial number appeared increased in the ventral forebrain of the 200mg Al/kg group. Cerebral Al levels were selectively increased in animals exposed to the lowest dose, while muscle granulomas had almost completely disappeared at 6 months in these animals.
We conclude that Alhydrogel1 injected at low dose in mouse muscle may selectively induce long-term Al cerebral accumulation and neurotoxic effects. To explain this unexpected result, an avenue that could be explored in the future relates to the adjuvant size since the injected suspensions corresponding to the lowest dose, but not to the highest doses, exclusively contained small agglomerates in the bacteria-size range known to favour capture and, presumably, transportation by monocyte-lineage cells. In any event, the view that Alhydrogel1 neurotoxicity obeys “the dose makes the poison” rule of classical chemical toxicity appears overly simplistic.
http://vaccinepapers.org/wp-content/uploads/Non-linear-dose-response-of-aluminium-hydroxide-adjuvant-particles-Selective-low-dose-neurotoxicity.pdf
FOR THOSE THAT STILL BELIEVE IN FLU SHOTS. More real info than you will likely be able to handle. In view of all this, NO ONE with any common sense would again take a flu vaccine.
These are the flu vaccine ingredients. What assurance of safety do you have and as well in available studies that these injected ingredients will not cause more harm to your health than any good done? I have never had a flu vaccine, I am 60 years old, and I never will never ever have a flu vaccine ever. I am not worried about it in the least. Flu vaccines make you more susceptible to pneumonia and other respiratory infections. Flu vaccines, if the strain of flu you get does not match the strains in the vaccine, you become much more at risk for severe flu and death, the reason for that is known as the concept of original antigenic sin, and it only applies to vaccines. You can as well go to the studies they did after the 2009-10 H1N1 fear mongered about false flu pandemic. Those studies were done in Canada. Get with the research.
Vaccine Ingredients and Manufacturer Information
(alphabetical order by vaccine)
Flu vaccines:
https://vaccines.procon.org/view.resource.php?resourceID=005206#influenza
https://vaccines.procon.org/view.resource.php?resourceID=005206#influenza-a-h5n1
https://vaccines.procon.org/view.resource.php?resourceID=005206#influenza-a-h1n1
It is time to end the federal recommendation that all women receive a flu shot during pregnancy. A CDC study released last week showed 200% or more increases in miscarriages among women who received a flu shot while pregnant. Women who got the H1N1 flu shot and a regular flu shot showed a 700% increase. And we know from a CDC study released in 2016 that flu shots cause a significant increase in autism among children whose mothers received the flu shot in the first trimester. The vaccine industry is trying to downplay the significance of these findings even though every flu vaccine package contains the following warning, "Safety and effectiveness of (this flu shot) have not been established in pregnant women or children less than 6 months of age." Which means that pregnant women have been getting flu shots as a standard procedure before we had the most basic safety information. It is time to put the health and safety of America's children before the interests of the vaccine industry. The federal government must issue an immediate revocation of the federal recommendation that all women receive flu shots during pregnancy.
Association Between Influenza Infection and Vaccination During Pregnancy and Risk of Autism Spectrum Disorder,
https://www.ncbi.nlm.nih.gov/pubmed/27893896
Association of spontaneous abortion with receipt of inactivated influenza vaccine containing H1N1pdm09 in 2012,
http://www.sciencedirect.com/science/article/pii/S0264410X17308666https://www.ncbi.nlm.nih.gov/pubmed/27893896
CDC STUDY SHOWS UP TO 7.7 TIMES THE RISK OF MISCARRIAGE AFTER INFLUENZA VACCINE
http://www.collective-evolution.com/2017/09/19/cdc-study-shows-up-to-7-7-times-the-risk-of-miscarriage-after-influenza-vaccine/
Vaccine. 2017 Sep 25;35(40):5314-5322. doi: 10.1016/j.vaccine.2017.06.069.
Association of spontaneous abortion with receipt of inactivated influenza vaccine containing H1N1pdm09 in 2010-11 and 2011-12.
Conclusion:
SAB was associated with influenza vaccination in the preceding 28 days. The association was significant only among women vaccinated in the previous influenza season with pH1N1-containing vaccine. This study does not and cannot establish a causal relationship between repeated influenza vaccination and SAB, but further research is warranted.
https://www.ncbi.nlm.nih.gov/pubmed/28917295
Increased Risk of Noninfluenza Respiratory Virus Infections Associated With Receipt of Inactivated Influenza Vaccine
https://academic.oup.com/cid/article/54/12/1778/455098
New Canadian studies suggest seasonal flu shot increased H1N1 risk
http://www.cidrap.umn.edu/news-perspective/2010/04/new-canadian-studies-suggest-seasonal-flu-shot-increased-h1n1-risk
Increased Risk of Noninfluenza Respiratory Virus Infections Associated With Receipt of Inactivated Influenza Vaccine
https://academic.oup.com/cid/article/54/12/1778/455098
'Serial' flu shots may limit body's ability to fight virus in future: researchers
http://www.ctvnews.ca/health/serial-flu-shots-may-limit-body-s-ability-to-fight-virus-in-future-researchers-1.3147903
Study: Prior-year vaccination cut flu vaccine effects in 2014-15
http://www.cidrap.umn.edu/news-perspective/2016/04/study-prior-year-vaccination-cut-flu-vaccine-effects-2014-15
Original Antigenic Sin Committed by Vaccination - VACCINE CHOICE CANADA
http://vaccinechoicecanada.com/resources/books-periodicals/original-antigenic-sin-committed-by-vaccination/
Complexity in the Immune System:
New Opportunities for Chemical
Engineering Research (directly addresses the subject of original antigenic sin)
http://www.mwdeem.rice.edu/mwdeem/perspective.pdf
Understanding Original Antigenic Sin in Influenza with a Dynamical System
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0023910
DISQUISITIONS ON ORIGINAL ANTIGENIC SIN
http://www.twiv.tv/JEM_OAS.pdf
Understanding Original Antigenic Sin in Influenza with a Dynamical System
http://www.nature.com/scientificamerican/journal/v311/n6/full/scientificamerican1214-80.html?WT.ec_id=SCIENTIFICAMERICAN-201412
ORIGINAL ANTIGENIC SIN: Why This Year’s Flu Vaccine May Make You Sicker
http://themountainsvoice.net/original-antigenic-sin-why-this-years-flu-vaccine-may-make-you-sicker-p264-161.htm
Confirmed! Flu Vaccine INCREASES Risk of Serious Pandemic Flu Illness
http://articles.mercola.com/sites/articles/archive/2012/09/18/flu-shot-increases-flu-illness.aspx
VACCINE INJURY COMPENSATION - Lawyers
We've helped recover more than $100 MILLION DOLLARS for vaccine injured clients in the past 3 years alone. (Many of the cases are for flu vaccine injury, take a look).
OUR VACCINE CASE RESULTS
Client Compensation for Vaccine Injuries
https://www.mctlawyers.com/vaccine-injury/cases/
https://www.mctlawyers.com/vaccine-injury/
Dr. Cammy Benton: CDC Admits There is No Science Behind the Annual Flu Vaccine
http://vaccineimpact.com/2017/dr-cammy-benton-cdc-admits-there-is-no-science-behind-the-annual-flu-vaccine/
Study: Annual Flu Shot Ineffective
Researchers with The Scripps Research Institute in La Jolla, California have published a study regarding the ineffectiveness of the annual influenza vaccine. The title of the study is A structural explanation for the low effectiveness of the seasonal influenza H3N2 vaccine. Each year, the CDC calculates how "effective" they believe the flu shot is based on prevalent strains of influenza in the population compared to strains of viruses used to compose the flu vaccine. This current study, however, challenges even the belief that if the right strains of influenza are predicted properly, that the flu shot is "effective," because those viruses contained in the flu shot mutate due to the fact that they are cultured in chicken eggs. The authors of the study state: "Seasonal influenza vaccine does not always confer protection in vaccinated individuals. Vaccine candidates are selected from clinical isolates based on their antigenic properties. It is common to use chicken eggs for culturing clinical isolates and for large-scale production of vaccines. However, influenza virus often mutates to adapt to being grown in chicken eggs, which can influence antigenicity and hence vaccine effectiveness." The lack of science supporting the manufacture and distribution of more than 300 million flu vaccines every year is well-known. Dr. Cammy Benton from North Carolina recently revealed in an interview with the VAXXED team that the CDC even admitted to her that the science was lacking regarding the effectiveness of the annual flu vaccines.
Read More...
http://vaccineimpact.com/2017/study-annual-flu-shot-ineffective/
CDC Caught Red-Handed Exaggerating Flu Cases and Deaths to Increase Vaccine Sales
http://vaccineimpact.com/2014/cdc-caught-red-handed-exaggerating-flu-cases-and-deaths-to-increase-vaccine-sales/
A Worm's Ovary Cells Become A Flu Vaccine Machine
https://www.npr.org/sections/health-shots/2013/01/18/169695011/a-worms-ovary-cells-become-a-flu-vaccine-machine
New Flu Vaccine Made with Armyworms and Insects Claims to be "Pure"
http://vaccineimpact.com/2017/new-flu-vaccine-made-with-armyworms-and-insects-claims-to-be-pure/
Vaccine injury fund tops $3.5 billion, as patients fight for payment
http://cronkitenewsonline.com/2015/05/vaccine-injury-fund-tops-3-5-billion-as-patients-fight-for-payment/
Here’s the shocking REAL reason why aluminum is added to vaccines
https://www.naturalnews.com/2017-09-01-heres-the-shocking-real-reason-why-aluminum-is-added-to-vaccines.html
---------------
Major corruption is going on.
“Authoritative” Vaccine Medical Information Sources Are Corrupted - December 5, 2017
“A foolish faith in authority is the worst enemy of the truth” — Albert Einstein The wisdom of this observation is borne out by empirical evidence demonstrating that so-called “authoritative” sources of medical information are thoroughly corrupted not only by industry manipulation but by government officials, and biased, financially conflicted academic gatekeepers of medical science — i.e., “expert panels” and journal editors. The most lucrative areas of medicine are the most corrupted by financial conflicts of interest. Our recent focus continues to be the untouchable subject; namely, the largely corrupted vaccine information base. The history of vaccines has been fashioned by eradicating inconvenient historical facts. The most troubling aspect of the corrupting influence of the powerful vaccine lobby is its apparent success in having averted the focus of the medical profession and academia: from the spiraling number of vaccine-injured children whose existence these authorities deny. However, evidence of their existence is demonstrated by the fraction of those who have been compensated by The U.S. Vaccine Injury Compensation Program (VICP). Public trust in professed authoritative sources for information about vaccine safety has evaporated because the “authoritative” government and non-government agencies have consistently misrepresented the safety data. Internal documents, obtained over the years through FOIA requests, have uncovered the concealed evidence that government officials eliminated damning vaccine safety data from the vaccine information base.
Read More...
http://vaccineimpact.com/2017/public-trust-in-professed-authoritative-sources-for-information-about-vaccine-safety-has-evaporated-because-the-authoritative-government-and-non-government-agencies-have-consistently/
The Vaccine Cartel: Largest Criminal Organization in the World - Why Your Flu Shot is Probably Illegal
http://vaccineimpact.com/2017/the-vaccine-cartel-largest-criminal-organization-in-the-world-why-your-flu-shot-is-probably-illegal/
Immunity and Impunity: Corruption in the State‐Pharma Nexus
Paddy Rawlinson, Western Sydney University, Australia
Abstract
Critical criminology repeatedly has drawn attention to the state‐corporate nexus as a site of corruption and other forms of criminality, a scenario exacerbated by the intensification of neoliberalism in areas such as health. The state‐pharmaceutical relationship, which increasingly influences health policy, is no exception. That is especially so when pharmaceutical products such as vaccines, a burgeoning sector of the industry, are mandated in direct violation of the principle of informed consent. Such policies have provoked suspicion and dissent as critics question the integrity of the state‐pharma alliance and its impact on vaccine safety. However, rather than encouraging open debate, draconian modes of governance have been implemented to repress and silence any form of criticism, thereby protecting the activities of the state and the pharmaceutical industry from independent scrutiny. The article examines this relationship in the context of recent legislation in Australia to intensify its mandatory regime around vaccines. It argues that attempts to undermine freedom of speech, and to systematically excoriate those who criticize or dissent from mandatory vaccine programs, function as a corrupting process and, by extension, serve to provoke the notion that corruption does indeed exist within the state‐pharma alliance.
Conclusion
If state power is about controlling populations, and corporate power about profit maximization, the vaccine industry feeds both. As such, more than any other area of public health, it demands a respect for human rights, for independent scientific inquiry, and the presence of an effective form of surveillance to ensure that abuses of power are minimized and harms avoided. Indeed, the very premise upon which claims for vaccines is made—that is, their contribution to the betterment of humankind—assumes the presence of these conditions of rights and respect rather than repression and disdain. The editor of The Lancet, Richard Horton, states the obvious, that ‘[i]t would seem within the spirit of scientific inquiry to pose questions that challenge received orthodoxies’ (2015). On this supposition, Edward Jenner, the father of vaccines, was able to pursue what was then regarded as unorthodox, controversial and dangerous thinking. He was afforded the freedom to debate with his peers, to present his findings, to develop his ideas, however contentious they might have been. Whether Jenner’s science was right or wrong is not the issue here. Rather, the fact that he could and did pursue what he genuinely believed would make a contribution to modern medicine is a testament to the spirit of free inquiry that drives scientific advancement. So too, the ability to choose how and when medical intervention can be applied to an individual’s body, without fear of demonisation, is a testament to the spirit of freedom of choice and conscience. When science serves state power, and the state serves the corporate world, each becomes corrupt and corrupting, and society moves one step closer to a repetition of medicine’s darkest time.
Correspondence: Paddy Rawlinson, Associate Professor in International Criminology, Human and Development Studies, Western Sydney University, Bankstown Campus, Horsley Road and Bullecourt Road, Bankstown 2200 NSW, Australia.
Just copy and paste this url into your browser, and you will get the full article.
Read more:
file:///C:/Users/LH/Downloads/447-1-1931-3-10-20171130.pdf
Corruption In Big Pharma’s Vaccine Industry
https://www.naturalblaze.com/2017/12/corruption-big-pharmas-vaccine-industry.html
http://www.thelibertybeacon.com/corruption-in-big-pharmas-vaccine-industry/
Attention Parents:
What Your Doctor Hasn't Told You About Vaccinations Could Put Your Child at Risk for Autism, Asthma, Allergies, Diabetes or Cancer.
Get the facts about vaccine risks, before you take any steps to vaccinate your child!
http://www.immunitionltd.com/ebook/vaccination.htm?hop=activists
Vaccine News
http://vaccines.news/
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And here, we have the next issue. Aluminum is not the only metallic ingredient in vaccines. Recent studies have as well identified vaccine contamination with other metals as well.
Dirty Vaccines: New Study Reveals Prevalence of Contaminants
Every Human Vaccine Tested Was Contaminated by Unsafe Levels of Metals and Debris Linked to Cancer and Autoimmune Disease, New Study Reports
Researchers examining 44 samples of 30 different vaccines found dangerous contaminants, including red blood cells in one vaccine and metal toxicants in every single sample tested – except in one animal vaccine.
Using extremely sensitive new technologies not used in vaccine manufacturing, Italian scientists reported they were “baffled” by their discoveries which included single particles and aggregates of organic debris including red cells of human or possibly animal origin and metals including lead, tungsten, gold, and chromium, that have been linked to autoimmune disease and leukemia.
In the study, published this week in the International Journal of Vaccines and Vaccination, the researchers led by Antonietta Gatti, of the National Council of Research of Italy and the Scientific Director of Nanodiagnostics, say their results “show the presence of micro- and nano-sized particulate matter composed of inorganic elements in vaccine samples” not declared in the products’ ingredients lists.
Lead particles were found in the cervical cancer vaccines, Gardasil and Cervarix, for example, and in the seasonal flu vaccine Aggripal manufactured by Novartis as well as in the Meningetec vaccine meant to protect against meningitis C.
Samples of an infant vaccine called Infarix Hexa (against diphtheria, tetanus, pertussis, hepatitis B, poliomyelitis and haemophilus influenzae type B) manufactured by GlaxoSmithKline was found to contain stainless steel, tungsten and a gold-zinc aggregate.
Other metal contaminants included platinum, silver, bismuth, iron, and chromium. Chromium (alone or in alloy with iron and nickel) was identified in 25 of the human vaccines from Italy and France that were tested.
GSK’s Fluarix vaccine for children three years and older contained 11 metals and aggregates of metals. Similar aggregates to those identified in the vaccines have been shown to be prevalent in cases of leukemia, the researchers noted.
Many of the vaccines contained iron and iron alloys which, according to the researchers, “can corrode and the corrosion products exert a toxicity affecting the tissues”.
READ MORE:
http://info.cmsri.org/the-driven-researcher-blog/dirty-vaccines-new-study-reveals-prevalence-of-contaminants
Dirty Vaccines – Part Two: What the Industry Knows and Isn't Telling You
http://www.greenmedinfo.com/blog/dirty-vaccines-part-two-what-industry-knows-and-isnt-telling-you
Breaking Interview: Lead Author of 'Dirty Vaccines' Study Speaks Out
http://www.greenmedinfo.com/blog/breaking-interview-lead-author-dirty-vaccines-study-speaks-out
Vaccine Contaminants, Nanotechnology, and Cancer
http://vaxxter.com/vaccine_contaminants_nano_cancer/
Metals Debris Found in Vaccine Supply
http://www.ecowatch.com/kennedy-metal-debris-vaccines-2276687112.html
New Quality-Control Investigations on Vaccines: Microand
Nanocontamination
http://medcraveonline.com/IJVV/IJVV-04-00072.pdf
Lead, Iron, Chromium and Other Metals Routinely Contaminate Vaccine Adjuvants, Industry Study Reports
http://info.cmsri.org/aluminum-and-your-health-blog/lead-iron-chromium-and-other-metals-routinely-contaminate-vaccine-adjuvants-industry-study-reports?utm_campaign=eBook%3A+Age+of+Aluminum&utm_content=46490849&utm_medium=social&utm_source=facebook
Little Things Matter: The Impact of Toxins on the Developing Brain
Canadian Environmental Health Atlas
We’ve been studying the impact of toxins on children for the past 30 years and reached the inescapable conclusion: little things matter. We’ve discovered that extremely low levels of toxins can impact brain development. We have also discovered that subtle shifts in the intellectual abilities of individual children have a big impact on the number of children in a population that are challenged or gifted. Steps should be taken to reduce children's exposure to toxins or suspected toxins. You can read more about how toxins impact brain development and the supportive documentation for this video here:
https://www.youtube.com/watch?v=E6KoMAbz1Bw
Vaccine contaminated with short and long chain DNA fragments when the antigen is grown on aborted fetal cell tissue. Many vaccines today are made that way.
STUDIES AND RESEARCHES ON AUTISM DISORDERS
http://soundchoice.org/autism/
Research and Publications
http://soundchoice.org/autism/autism-research/
New CDC Guidelines: 5 Year-Old Can Receive up to 19 Vaccinations in One Month
http://vaccineimpact.com/2017/new-cdc-guidelines-5-year-old-can-receive-up-to-19-vaccinations-in-one-month/
Vaccine Schedules
https://www.cdc.gov/vaccines/schedules/index.html
Big Pharma and Big Profits: The Multibillion Dollar Vaccine Market
New Report says “Vaccine Market” Worth $61 Billion by 2020
https://www.globalresearch.ca/big-pharma-and-big-profits-the-multibillion-dollar-vaccine-market/5503945
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Did you know that there is a significant financial incentive for doctors to vaccinate? Below, you will find what that involves, and how much they receive.
How Much Money Do Pediatricians Really Make From Vaccines?
https://wellnessandequality.com/tag/blue-cross-blue-shields-physician-incentive-program/
2017 Performance
Recognition Program
PROVIDER INCENTIVE PROGRAM FOR:
• BCN Commercial HMO
• BCN AdvantageSM HMO-POS
• BCBSM Medicare Plus BlueSM PPO
http://thephysicianalliance.org/images/FilesDocuments/2017_BCN_BCBSM_PRPBooklet_Final122016.pdf
The actual payoff amount to pediatricians for coercing parents into vaccinating.
https://community.babycenter.com/post/a63644578/the-actual-payoff-amount-to-pediatricians-for-coercing-parents-into-vaccinating.
http://thephysicianalliance.org/index.php/incentive-programs
The Unknown Reasons Doctors Push Vaccines
Blue Cross, Blue Shield, Blue Care Network of Michigan publishes online a shameless and bold report of how much cash they reward physicians for performing certain tests, and which apparently acts as an incentive to over-prescribe, thus inflating the costs of U.S. healthcare, which should be illegal.
Blue Cross/Blue Shield published the 2016 Performance Recognition Program, a 28-page report indicating how medical insurance companies actually increase the costs of healthcare!
Look what we find on the BC/BS page “Childhood Immunizations—Combo 10”!
If MDs meet a target of 63% of eligible member patients, they will receive a payout of $400 per completed eligible member. Wow! Now you know one of the key reasons why parents are hounded to vaccinate their infants and toddlers. Gelt, pecunia, greenbacks—whatever you call M-O-N-E-Y.
Read MORE:
http://www.activistpost.com/2017/08/unknown-reasons-doctors-push-vaccines.html
TOXIC INGREDIENTS FOUND IN VACCINES: * aluminum hydroxide * aluminum phosphate * ammonium sulfate *amphotericin B * animal tissues: pig blood, horse blood, rabbit brain * dog kidney, monkey kidney * chick embryo, chicken egg, duck egg * calf (bovine) serum * betapropiolactone * fetal bovine serum * formaldehyde * formalin * gelatin * glycerol * human diploid cells (originating from human aborted fetal tissue) * hydrolized gelatin * mercury thimerosol (thimerosal, Merthiolate) * monosodium glutamate (MSG) * neomycin * neomycin sulfate * phenol red indicator * phenoxyethanol (antifreeze) * potassiumdiphosphate * potassium monophosphate * polymyxin B * polysorbate 20 * polysorbate 80 porcine (pig) pancreatic hydrolysate of casein * residual MRC5 proteins * sorbitol * tri(n)butylphosphate * VERO cells, a continuous line of monkey kidney cells * washed sheep red blood plus (source), CDC’s Vaccine Excipients Table:
DISEASES FROM VACCINES:* Allergies * Asthma * Attention Deficit Disorder *Autism *Auto-immune Diseases * Blindness * Brain Cell Loss *Cancer * Central NervousSystem Damage* Deafness * Developmental Damage *DEATH * Diabetes * Epilepsy *Learning Disabilities * Leukemia * Multiple Sclerosis * Neurological Disease *Organ Disease * Psoriasis * Seizures * Shaken Baby Syndrome * Synergistic Toxicity *SIDS * Total Paralysis *
https://www.facebook.com/notes/sallie-o-elkordy-for-mayor-vaccine-free-nyc/proposed-executive-order-eo-vaccine-free-2017/1637470476269264/
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More studies:
A case-control study of serious autoimmune adverse events following hepatitis B immunization
Abstract
Hepatitis B infection is one of the most important causes of acute and chronic liver disease. During the 1980s, genetically engineered hepatitis B vaccines (HBVs) were introduced in the United States. A large-series of serious autoimmune conditions have been reported following HBVs, despite the fact that HBVs have been reported to be "generally well-tolerated." A case-control epidemiological study was conducted to evaluate serious autoimmune adverse events prospectively reported to the vaccine adverse events reporting system (VAERS) database following HBVs, in comparison to an age, sex, and vaccine year matched unexposed tetanus-containing vaccine (TCV) group for conditions that have been previously identified on an a priori basis from case-reports. Adults receiving HBV had significantly increased odds ratios (OR) for multiple sclerosis (OR = 5.2, p < 0.0003, 95% Confidence Interval (CI) = 1.9 - 20), optic neuritis (OR = 14, p < 0.0002, 95% CI = 2.3 - 560), vasculitis (OR = 2.6, p < 0.04, 95% CI = 1.03 - 8.7), arthritis (OR = 2.01, p < 0.0003, 95% CI = 1.3 - 3.1), alopecia (OR = 7.2, p < 0.0001, 95% CI = 3.2 - 20), lupus erythematosus (OR = 9.1, p < 0.0001, 95% CI = 2.3 - 76), rheumatoid arthritis (OR = 18, p < 0.0001, 95% CI = 3.1 - 740), and thrombocytopenia (OR = 2.3, p < 0.04, 95% CI = 1.02 - 6.2) in comparison to the TCV group. Minimal confounding or systematic error was observed. Despite the negative findings of the present study regarding the rare serious adverse effects of HBVs, it is clear that HBV does, indeed, offer significant benefits, but it is also clear that chances of exposure to hepatitis B virus in adults is largely life-style dependent. Adults should make an informed consent decision, weighing the risks and benefits of HBV, as to whether or not to be immunized.
https://www.researchgate.net/publication/7558011_A_case-control_study_of_serious_autoimmune_adverse_events_following_hepatitis_B_immunization
Hepatitis B vaccine induces apoptotic death in Hepa1-6 cells
Abstract
Vaccines can have adverse side-effects, and these are predominantly associated with the inclusion of chemical additives such as aluminum hydroxide adjuvant. The objective of this study was to establish an in vitro model system amenable to mechanistic investigations of cytotoxicity induced by hepatitis B vaccine, and to investigate the mechanisms of vaccine-induced cell death. The mouse liver hepatoma cell line Hepa1-6 was treated with two doses of adjuvanted (aluminium hydroxide) hepatitis B vaccine (0.5 and 1 μg protein per ml) and cell integrity was measured after 24, 48 and 72 h. Hepatitis B vaccine exposure increased cell apoptosis as detected by flow cytometry and TUNEL assay. Vaccine exposure was accompanied by significant increases in the levels of activated caspase 3, a key effector caspase in the apoptosis cascade. Early transcriptional events were detected by qRT-PCR. We report that hepatitis B vaccine exposure resulted in significant upregulation of the key genes encoding caspase 7, caspase 9, Inhibitor caspase-activated DNase (ICAD), Rho-associated coiled-coil containing protein kinase 1 (ROCK-1), and Apoptotic protease activating factor 1 (Apaf-1). Upregulation of cleaved caspase 3,7 were detected by western blot in addition to Apaf-1 and caspase 9 expressions argues that cell death takes place via the intrinsic apoptotic pathway in which release of cytochrome c from the mitochondria triggers the assembly of a caspase activation complex. We conclude that exposure of Hepa1-6 cells to a low dose of adjuvanted hepatitis B vaccine leads to loss of mitochondrial integrity, apoptosis induction, and cell death, apoptosis effect was observed also in C2C12 mouse myoblast cell line after treated with low dose of vaccine (0.3, 0.1, 0.05 μg/ml). In addition In vivo apoptotic effect of hepatitis B vaccine was observed in mouse liver.
https://www.researchgate.net/publication/221751427_Hepatitis_B_vaccine_induces_apoptotic_death_in_Hepa1-6_cells
Selection of Hepatitis B Virus (HBV) Vaccine Escape Mutants in HBV-Infected and HBV/HIV-Coinfected Patients Failing Antiretroviral Drugs With Anti-HBV Activity
Abstract
Background: Given the overlap between envelope and polymerase in the hepatitis B virus (HBV) genome, changes in antigenic sites of the HBV surface antigen may occur as a result of selection of drug-resistance mutations.
Methods: Serum HBV-DNA was isolated from 71 patients with chronic hepatitis B receiving anti-HBV drugs for longer than 12 months, 52 of whom were HIV-positive. The reverse transcriptase/envelope gene from each HBV isolate was amplified using a nested polymerase chain reaction (PCR) covering 720 bp (aa 48 to 288), which includes all known nucleos(t)ide analogue resistance mutations in HBV.
Results: All but 13 patients had received lamivudine. Of the rest, 10 HBV-monoinfected subjects had received adefovir and 3 HBV/HIV-coinfected patients had been treated with tenofovir. Only lamivudine-resistance-associated mutations produced changes in the HBV envelope antigenic sites. Lamivudine resistance mutations were more frequent in HBV genotype A than D (P = 0.014). Contrary to monoinfected individuals, HBV genotype A was the predominant genotype among HBV/HIV-coinfected patients. The triple-HBV mutant rtV173L + rtL180M + rtM204V, which has been shown to produce a diminished hepatitis B surface (HBs) antigen-antibody binding, was found in 3 individuals, all coinfected with HIV and HBV.
Conclusion: Circulation of HBV encoding envelope mutations with diminished HBs antigen-antibody binding as result of selection of drug-resistance mutations may occur, particularly in patients infected with HBV genotype A, the most prevalent genotype among HBV/HIV-coinfected patients. Such mutations might represent a public health concern because of the potential risk of transmission of HBV drug- and vaccine-resistant strains.
http://journals.lww.com/jaids/Fulltext/2007/11010/Selection_of_Hepatitis_B_Virus__HBV__Vaccine.4.aspx
Increased Risk of Noninfluenza Respiratory Virus Infections Associated With Receipt of Inactivated Influenza Vaccine
https://academic.oup.com/cid/article/54/12/1778/455098
New Canadian studies suggest seasonal flu shot increased H1N1 risk
http://www.cidrap.umn.edu/news-perspective/2010/04/new-canadian-studies-suggest-seasonal-flu-shot-increased-h1n1-risk
Increased Risk of Noninfluenza Respiratory Virus Infections Associated With Receipt of Inactivated Influenza Vaccine
https://academic.oup.com/cid/article/54/12/1778/455098
'Serial' flu shots may limit body's ability to fight virus in future: researchers
http://www.ctvnews.ca/health/serial-flu-shots-may-limit-body-s-ability-to-fight-virus-in-future-researchers-1.3147903
Study: Prior-year vaccination cut flu vaccine effects in 2014-15
http://www.cidrap.umn.edu/news-perspective/2016/04/study-prior-year-vaccination-cut-flu-vaccine-effects-2014-15
Original Antigenic Sin Committed by Vaccination - VACCINE CHOICE CANADA
http://vaccinechoicecanada.com/resources/books-periodicals/original-antigenic-sin-committed-by-vaccination/
Complexity in the Immune System:
New Opportunities for Chemical
Engineering Research (directly addresses the subject of original antigenic sin)
http://www.mwdeem.rice.edu/mwdeem/perspective.pdf
Understanding Original Antigenic Sin in Influenza with a Dynamical System
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0023910
DISQUISITIONS ON ORIGINAL ANTIGENIC SIN
http://www.twiv.tv/JEM_OAS.pdf
Understanding Original Antigenic Sin in Influenza with a Dynamical System
http://www.nature.com/scientificamerican/journal/v311/n6/full/scientificamerican1214-80.html?WT.ec_id=SCIENTIFICAMERICAN-201412
ORIGINAL ANTIGENIC SIN: Why This Year’s Flu Vaccine May Make You Sicker
http://themountainsvoice.net/original-antigenic-sin-why-this-years-flu-vaccine-may-make-you-sicker-p264-161.htm
Confirmed! Flu Vaccine INCREASES Risk of Serious Pandemic Flu Illness
http://articles.mercola.com/sites/articles/archive/2012/09/18/flu-shot-increases-flu-illness.aspx
VACCINE INJURY COMPENSATION - Lawyers
We've helped recover more than $100 MILLION DOLLARS for vaccine injured clients in the past 3 years alone. (Many of the cases are for flu vaccine injury, take a look).
OUR VACCINE CASE RESULTS
Client Compensation for Vaccine Injuries
https://www.mctlawyers.com/vaccine-injury/cases/
https://www.mctlawyers.com/vaccine-injury/
Dr. Cammy Benton: CDC Admits There is No Science Behind the Annual Flu Vaccine
http://vaccineimpact.com/2017/dr-cammy-benton-cdc-admits-there-is-no-science-behind-the-annual-flu-vaccine/
Study: Annual Flu Shot Ineffective
Researchers with The Scripps Research Institute in La Jolla, California have published a study regarding the ineffectiveness of the annual influenza vaccine. The title of the study is A structural explanation for the low effectiveness of the seasonal influenza H3N2 vaccine. Each year, the CDC calculates how "effective" they believe the flu shot is based on prevalent strains of influenza in the population compared to strains of viruses used to compose the flu vaccine. This current study, however, challenges even the belief that if the right strains of influenza are predicted properly, that the flu shot is "effective," because those viruses contained in the flu shot mutate due to the fact that they are cultured in chicken eggs. The authors of the study state: "Seasonal influenza vaccine does not always confer protection in vaccinated individuals. Vaccine candidates are selected from clinical isolates based on their antigenic properties. It is common to use chicken eggs for culturing clinical isolates and for large-scale production of vaccines. However, influenza virus often mutates to adapt to being grown in chicken eggs, which can influence antigenicity and hence vaccine effectiveness." The lack of science supporting the manufacture and distribution of more than 300 million flu vaccines every year is well-known. Dr. Cammy Benton from North Carolina recently revealed in an interview with the VAXXED team that the CDC even admitted to her that the science was lacking regarding the effectiveness of the annual flu vaccines.
Read More...
http://vaccineimpact.com/2017/study-annual-flu-shot-ineffective/
CDC Caught Red-Handed Exaggerating Flu Cases and Deaths to Increase Vaccine Sales
http://vaccineimpact.com/2014/cdc-caught-red-handed-exaggerating-flu-cases-and-deaths-to-increase-vaccine-sales/
A Worm's Ovary Cells Become A Flu Vaccine Machine
https://www.npr.org/sections/health-shots/2013/01/18/169695011/a-worms-ovary-cells-become-a-flu-vaccine-machine
New Flu Vaccine Made with Armyworms and Insects Claims to be "Pure"
http://vaccineimpact.com/2017/new-flu-vaccine-made-with-armyworms-and-insects-claims-to-be-pure/
Vaccine injury fund tops $3.5 billion, as patients fight for payment
http://cronkitenewsonline.com/2015/05/vaccine-injury-fund-tops-3-5-billion-as-patients-fight-for-payment/
The Vaccine Cartel: Largest Criminal Organization in the World - Why Your Flu Shot is Probably Illegal
http://vaccineimpact.com/2017/the-vaccine-cartel-largest-criminal-organization-in-the-world-why-your-flu-shot-is-probably-illegal/
A video of Dorit's speaking and facial situation; ischemic stroke.
https://www.facebook.com/vaccinationinformationnetwork/videos/vb.69667273997/10156398876058998/?type=2&theater
Again, the answers have been there all along. Answers that the CDC and the pro-vaccinator's, refuse to see.
Dr. Andrew Moulden: Learning to Identify Vaccine Damage
https://vaccineimpact.com/2015/dr-andrew-moulden-learning-to-identify-vaccine-damage/
Dr. Andrew Moulden's Tolerance Lost: Part 1 - "The Problem"
https://www.youtube.com/watch?v=Re8UI8aCLpM
Tolerance Lost Vol 1/3 - 1 of 16 - Moulden
https://www.youtube.com/watch?v=RZXM-TKvLN8
Health Canada Corruption - Dr. Andrew Moulden
Dr. Andrew Moulden getting the message of truth out to people about the extreme corporate corruption of Health Canada, the FDA, and other corporate controlled medical care entities that are, in fact, destroying peoples health with vaccines and other chemical pharmaceutical drugs.
https://www.dailymotion.com/video/xbo5vf
Are You Crooked? (Forrest Maready)
https://www.youtube.com/watch?v=4lf8fdiU1Qk
ARE YOU CROOKED?
What our faces are trying to tell us.
http://areyoucrooked.com/
https://www.facebook.com/vaccinationinformationnetwork/videos/vb.69667273997/10156398876058998/?type=2&theater
Again, the answers have been there all along. Answers that the CDC and the pro-vaccinator's, refuse to see.
Dr. Andrew Moulden: Learning to Identify Vaccine Damage
https://vaccineimpact.com/2015/dr-andrew-moulden-learning-to-identify-vaccine-damage/
Dr. Andrew Moulden's Tolerance Lost: Part 1 - "The Problem"
https://www.youtube.com/watch?v=Re8UI8aCLpM
Tolerance Lost Vol 1/3 - 1 of 16 - Moulden
https://www.youtube.com/watch?v=RZXM-TKvLN8
Health Canada Corruption - Dr. Andrew Moulden
Dr. Andrew Moulden getting the message of truth out to people about the extreme corporate corruption of Health Canada, the FDA, and other corporate controlled medical care entities that are, in fact, destroying peoples health with vaccines and other chemical pharmaceutical drugs.
https://www.dailymotion.com/video/xbo5vf
Are You Crooked? (Forrest Maready)
https://www.youtube.com/watch?v=4lf8fdiU1Qk
ARE YOU CROOKED?
What our faces are trying to tell us.
http://areyoucrooked.com/
I have always seen the vaccine truth situation, as a WAR!!! A war against evil and tyranny. Loading real vaccine truth bombs daily, we go to WAR in speaking the vaccine truth. We do that to hopefully save one more family, and one more child, teen, or adult from this toxic and known contaminated, now known massive level of vaccine harm; and that through real vaccine truth education.
Thank you for reading this page.
